Interactions between mycoplasma lipid-associated membrane proteins and the host cells
Interactions between mycoplasma lipid-associated membrane proteins and the host cells
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DOI：
10.1631/jzus.2006.b0342
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发表时间：
2006-05
期刊：
影响因子：
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通讯作者：
Xiaoxing You;Yan-hua Zeng;Yi-mou Wu
中科院分区：
文献类型：
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作者：
Xiaoxing You;Yan-hua Zeng;Yi-mou Wu
支原体是自然界中广泛分布的一类无壁原核生物，其中一些对人畜具有致病性。有许多脂蛋白锚定在质膜的外表面，称为脂质相关膜蛋白（LAMP）。LAMP是高度抗原性的，并且可以经历相位和大小变化，并且通过Toll样受体（TLR）2和6被先天免疫系统识别。LAMPs可以调节免疫系统，诱导免疫细胞凋亡或死亡。此外，它们可能与宿主细胞的恶性转化有关，也被认为是艾滋病进展的辅助因子。
Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also considered to be cofactors in the progression of AIDS.