Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women
Seasonal changes in plasma 25-hydroxyvitamin D concentrations of young American black and white women
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DOI：
10.1093/ajcn/67.6.1232
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发表时间：
1998-06-01
影响因子：
7.1
通讯作者：
Dawson-Hughes, B
中科院分区：
文献类型：
--
作者：
Harris, SS;Dawson-Hughes, B
对来自波士顿的51名20-40岁黑人和39名20-40岁白色女性的25-羟基维生素D浓度的季节性变化进行了研究。在2月或3月（2月至3月）、6月或7月（6月至7月）、10月或11月（6月至11月）以及随后的2月或3月（2月至3月）进行个体测量。在研究结束时分批分析4次访视的样本。在所有时间点，黑人妇女的血浆25-羟基维生素D显著低于白色妇女，包括价值最低的2月至3月（黑人为30.2 +/- 19.7 nmol/L，白色女性为60.0 +/- 21.4 nmol/L）和6 - 7月最高（黑人女性为41.0 +/- 16.4 nmol/L，白色女性为85.4 +/- 33.0 nmol/L）。尽管两组妇女的25-羟维生素D浓度都有季节性变化，但黑人妇女在2 - 3月和6 - 7月之间的平均增幅较小（10.8 +/- 14.0 nmol/L，而白色女性为25.4 +/- 29.8 nmol/L，P = 0.006），且其季节变化的总体幅度较低（P = 0.001），血清甲状旁腺素浓度在2 ~ 3月显著升高黑人女性（P < 0.005）（5.29 +/- 2.32 pmol/L）高于白色女性（4.08 +/- 1.41 pmol/L），并与黑人中的25-羟基维生素D呈显著负相关（r =-0.42，P = 0.002），而白人则不然（r =-0.19，P = 0.246）。虽然黑人的骨密度和骨折率比白人低，但由于25-羟维生素D浓度低而导致的甲状旁腺激素浓度升高可能对黑人人群的骨骼产生负面影响。
Seasonal changes in 25-hydroxyvitamin D concentrations were studied in 51 black and 39 white women aged 20-40 y from Boston. Individual measurements were made in February or March (February-March), June or July (June July), October or November (October-November), and the following February or March (February-March). Samples from the four visits were analyzed in batches at the end of the study. Plasma 25-hydroxyvitamin D was substantially lower in black than in white women at all the time points, including February-March when values were lowest (30.2 +/- 19.7 nmol/L in black and 60.0 +/- 21.4 nmol/L in white women) and June-July when they were highest (41.0 +/- 16.4 nmol/L in black and 85.4 +/- 33.0 nmol/L in white women). Although both groups showed seasonal variation in 25-hydroxyvitamin D concentrations, the mean increase between February-March and June-July was smaller in black women (10.8 +/- 14.0 nmol/L compared with 25.4 +/- 29.8 nmol/L in white women, P = 0.006) and their overall amplitude of seasonal change was lower (P = 0.001), Concentrations of serum parathyroid hormone in February-March were significantly higher (P < 0.005) in black women (5.29 +/- 2.32 pmol/L) than in white women (4.08 +/- 1.41 pmol/L) and were significantly inversely correlated with 25-hydroxyvitamin D in blacks (r = -0.42, P = 0.002) but not in whites (r = -0.19, P = 0.246), Although it is well established that blacks have denser bones and lower fracture rates than whites, elevated parathyroid hormone concentrations resulting from low 25-hydroxyvitamin D concentrations may have negative skeletal consequences within black populations.