Tissue plasminogen activator thrombolysis during surgical evacuation of experimental subretinal hemorrhage.
Tissue plasminogen activator thrombolysis during surgical evacuation of experimental subretinal hemorrhage.
复制标题
实验性视网膜下出血手术清除期间组织纤溶酶原激活物溶栓。
DOI：
10.1016/s0161-6420(92)31939-6
复制
发表时间：
1992
期刊：
影响因子：
13.7
通讯作者：
Hernandez,E
中科院分区：
文献类型：
--
作者：
Johnson,MW;Olsen,KR;Hernandez,E
为了评估术中溶栓在视网膜下大出血手术清除中的作用，作者研究了组织型纤溶酶原激活剂(TPA)通过小引流视网膜切开术促进实验性视网膜下血块清除的能力。在兔眼中，单次视网膜下注射浓度高达250μg/ml的组织型纤溶酶原激活剂在3小时内未能产生显著的(50%)凝块溶解。然而，重复视网膜下冲洗和抽吸tPA(50μg/ml)可导致兔术中血栓的渐进性溶解，并允许6只猫眼(100%)通过小引流视网膜切开术完全排出血液。反复大力视网膜下冲洗生理盐水对兔眼血块大小无明显影响。在tPA辅助下手术清除视网膜下血液后的猫眼组织病理学检查显示，2只眼保留了外层视网膜，4只眼外层视网膜严重萎缩。
To assess the role for intraoperative thrombolysis during surgical evacuation of massive subretinal hemorrhage, the authors studied the ability of tissue plasminogen activator (tPA) to facilitate removal of an experimental subretinal blood clot through a small drainage retinotomy. In rabbit eyes, a single subretinal injection of tissue plasminogen activator in concentrations of up to 250 μg/ml failed to produce significant (>50%) clot dissolution during a 3-hour period. However, repetitive subretinal lavage and aspiration with tPA (50 μg/ml) resulted in progressive intraoperative clot dissolution in rabbits and allowed complete evacuation of blood through a small drainage retinotomy in 6 (100%) of 6 cat eyes. Repetitive vigorous subretinal irrigation with saline solution had no discernible effect on clot size in rabbit eyes. Histopathologic examination of cat eyes following tPA-assisted surgical evacuation of subretinal blood showed preservation of the outer retina in 2 eyes and severe atrophy of the outer retina in 4 eyes.