Anti-β2-glycoprotein I and antiphosphatidylserine antibodies are predictors of arterial thrombosis in patients with antiphospholipid syndrome
Anti-β2-glycoprotein I and antiphosphatidylserine antibodies are predictors of arterial thrombosis in patients with antiphospholipid syndrome
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DOI：
10.1309/yvq6px76xmym3j29
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发表时间：
2004-01-01
影响因子：
3.5
通讯作者：
Fink, CA
中科院分区：
文献类型：
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作者：
Lopez, LR;Dier, KJ;Fink, CA
在 90 名系统性红斑狼疮 (SLE) 患者和 100 名 APS 患者中评估了 4 种抗磷脂抗体与抗磷脂综合征 (APS) 临床表现的预测价值 (PV) 和关联。 APS 患者分为动脉血栓形成、静脉血栓形成和妊娠发病亚组。通过酶联免疫吸附测定法测定 IgG、IgM 和 IgA 抗心磷脂 (aCL)、抗磷脂酰丝氨酸 (aPS)、抗 β(2)-糖蛋白 I（抗 B2GPI）和抗凝血酶原 (aPT) 抗体。单独而言，抗 B2GPI 和 aPS 抗体对 APS 住院 SLE 患者具有最强的 PV（864%-94.1%；P < .001）。当存在 2 种或更多抗体时，APS 的 PV 达到 100%。同样，与静脉血栓形成 (80%-92%；P = .01) 相比，抗 B2GPI 和 aPS 抗体具有更强的 PV 和与动脉血栓形成的关联 (87%-95%；P < .001)。所有抗体均显示出较弱的 PV 值以及与妊娠发病率的相关性。这些结果表明抗 B2GPI 抗体在动脉血栓形成中具有重要的致病作用。此外，抗B2GPI和aPS抗体似乎为APS的实验室评估提供了最佳的诊断价值。
The predictive value (PV) and association of 4 antiphospholipid antibodies with clinical manifestations of the antiphospholipid syndrome (APS) were evaluated in 90 patients with systemic lupus erythematosus (SLE) and 100 with APS. Patients with APS were classified into arterial thrombosis, venous thrombosis, and pregnancy morbidity subgroups. IgG, IgM, and IgA anticardiolipin (aCL), antiphosphatidylserine (aPS), anti-beta(2)-glycoprotein I (anti-B2GPI), and antiprothrombin (aPT) antibodies were determined by enzyme-linked immunosorbent assay. Individually, anti-B2GPI and aPS antibodies had the strongest PV for APS (864%-94.1%; P < .001) inpatients with SLE. The PV for APS reached 100% when 2 or more antibodies were present. Similarly, anti-B2GPI and aPS antibodies had a stronger PV and association for arterial thrombosis (87%-95%; P < .001) compared with venous thrombosis (80%-92%; P = .01). Weak PV and association with pregnancy morbidity were seen with all antibodies. These results suggest an important pathogenic role of anti-B2GPI antibodies in arterial thrombosis. In addition, anti-B2GPI and aPS antibodies seem to provide the best diagnostic value for the laboratory assessment of APS.