Early origin and recent expansion of Plasmodium falciparum
Early origin and recent expansion of Plasmodium falciparum
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DOI：
10.1126/science.1081449
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发表时间：
2003-04-11
期刊：
影响因子：
56.9
通讯作者：
Su, XZ
中科院分区：
文献类型：
--
作者：
Joy, DA;Feng, XR;Su, XZ
恶性疟原虫在非洲的出现，在过去的6000年中，由于人类行为和蚊子传播的级联变化，最近被假设。在这里，我们提供了遗传学证据，证明大约1万年前非洲疟疾寄生虫种群突然增加，然后根据全球100个线粒体DNA序列的变异迁移到其他地区。然而，世界和一些地区的人口似乎更老（50，000至100，000岁），这表明更早的一波移民离开非洲，也许在更新世人类迁移期间。
The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, followed by migration to other regions on the basis of variation in 100 worldwide mitochondrial DNA sequences. However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings.