The lateralization of left hippocampal CA3 during the retrieval of spatial working memory
The lateralization of left hippocampal CA3 during the retrieval of spatial working memory
复制标题
空间工作记忆检索过程中左侧海马 CA3 的偏侧化
DOI：
10.1038/s41467-020-16698-4
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发表时间：
2020-06-09
影响因子：
16.6
通讯作者：
Qing, Hong
中科院分区：
文献类型：
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作者：
Song, Da;Wang, Deheng;Qing, Hong
海马CA 3区参与空间工作记忆（SWM）的形成，但CA 3区神经元作用于SWM的哪个阶段以及CA 3区功能是否在SWM中发生偏侧化尚不清楚。在这里，我们揭示了增加的神经活动在样本和选择阶段的SWM。左CA 3（LCA 3）神经元在正确与错误试验期间的选择阶段显示出比右CA 3（RCA 3）神经元更高的敏感性。LCA 3在选择阶段先于RCA 3启动点火。LCA 3锥体神经元的光遗传抑制仅在选择阶段破坏SWM。此外，我们发现，小清蛋白（PV）神经元，而不是胆碱能神经元在内侧隔（DB是胆碱能神经元），可以直接投射到一侧CA 3。选择性抑制MS中投射到LCA 3的PV神经元损害SWM。研究结果表明，MSPV-LCA 3投射在操纵LCA 3的偏侧化中起着至关重要的作用，在检索SWM。
The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.