HEPATITIS-C VIRUS-INFECTION IN A SEXUALLY ACTIVE INNER-CITY POPULATION - THE POTENTIAL FOR HETEROSEXUAL TRANSMISSION
HEPATITIS-C VIRUS-INFECTION IN A SEXUALLY ACTIVE INNER-CITY POPULATION - THE POTENTIAL FOR HETEROSEXUAL TRANSMISSION
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DOI：
10.1007/bf01739007
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发表时间：
1994-03-01
期刊：
影响因子：
7.5
通讯作者：
FISCHL, MA
中科院分区：
文献类型：
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作者：
DAIKOS, GL;LAI, S;FISCHL, MA
丙型肝炎病毒（HCV）感染的患病率和相关的危险因素，在内城性活跃的异性恋人群参与了一项前瞻性研究，以评估人类免疫缺陷病毒1型（HIV-1）的异性传播进行了检查。既往有注射药物使用史或接受血液制品的个体从研究中排除。在571名参与者中，25名（4.4%）为HCV血清阳性，39名（7%）为HIV血清阳性，125名（22%）为B型肝炎病毒（HBV）血清阳性。多因素分析显示，在过去5年内有10个以上异性伴侣的人，（OR = 3.7; 95%CI = 1.3，10.2; P = 0.01），每周性行为超过1次（OR = 3.3; 95% CI = 1.1，10.1; P = 0.04），有抗B核心抗原（HBc）抗体（OR = 2.9; 95% CI = 1.1，7.4; P = 0.03）、HIV-1抗体（OR = 5.8; 95% CI = 1.9; 17.6; P = 0.002）与HCV感染独立相关。这些研究结果表明，HCV的异性传播可能发生在市中心性活跃的异性恋人群中。
The prevalence of hepatitis C virus (HCV) infection and associated risk factors in an inner city sexually active heterosexual population participating in a prospective study for the evaluation of heterosexual transmission of human immunodeficiency virus type-1 (HIV-1) were examined. Individuals,vith prior history of injection drug use or receipt of blood products were excluded from the study. Of 571 participants, 25 (4.4%) were seropositive for HCV, 39 (7%) for HIV, and 125 (22%) for hepatitis B virus (HBV). Multivariate analysis revealed that those with more than ten heterosexual partners in the past 5 years (OR = 3.7; 95% CI = 1.3, 10.2; P = 0.01), engaging in sexual practices more than once per week (OR = 3.3; 95% CI = 1.1, 10.1; P = 0.04), with antibody to hepatitis B core (HBc) antigen(OR = 2.9; 95% CI = 1.1, 7.4; P = 0.03), and antibody to HIV-1 (OR = 5.8; 95% CI = 1.9; 17.6; P = 0.002) were independently associated with HCV infection. These findings suggest that heterosexual transmission of HCV may occur in an inner city sexually active heterosexual population.