Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan
Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan
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DOI：
10.1080/14397595.2017.1366093
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发表时间：
2018-01-01
影响因子：
2.2
通讯作者：
Yoshizaki, Kazuyuki
中科院分区：
文献类型：
--
作者：
Fujimoto, Shino;Koga, Tomohiro;Yoshizaki, Kazuyuki
目的：目的：探讨Castleman病（CD）的诊断标准和疾病严重程度分级，并描述日本人群中人类疱疹病毒8型（HHV-8）阴性的特发性多中心CD（iMCD）的临床和病理特征。随后，我们分析了142例患者分类为iMCD使用全国范围内的日本患者registration.Results：我们提出了初步的诊断标准和疾病严重程度分类CD根据我们的讨论。此外，我们还对疾病活动性评分提出了建议。我们确定了根据这些诊断标准诊断的iMCD患者的临床和病理特征。在疾病严重程度分类中，37%、33%和30%的患者被分为轻度、中度和重度疾病，分别为。需要进一步的研究来验证它们是否可以区分CD和其他炎性疾病，并确定它们的敏感性和特异性。
Objectives: To determine the tentative diagnostic criteria and disease severity classification for Castleman disease (CD) and describe the clinical and pathologic features among human herpesvirus 8 (HHV-8) negative idiopathic multicentric CD (iMCD) in the Japanese population.Methods: We established the working groups for the research of CD in Japan and had meetings to discuss and define the tentative diagnostic criteria and disease severity classification for CD. We subsequently analyzed 142 patients classified into iMCD by using the nationwide Japanese patient registry.Results: We proposed the preliminary diagnostic criteria and disease severity classification for CD based on our discussion. In addition, we made a proposal for the disease activity score. We identified clinical and pathological features of patients with iMCD diagnosed by these diagnostic criteria. In the disease severity classification, 37, 33 and 30% patients were categorized into mild, moderate and severe diseases, respectively.Conclusion: This is the first proposal for diagnosis and classification of CD by the Japanese group. Further studies are required to validate whether they can distinguish CD from other inflammatory diseases and to determine their sensitivity and specificity.