The design and interpretation of case-control studies of perinatal mortality.
The design and interpretation of case-control studies of perinatal mortality.
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围产期死亡率病例对照研究的设计和解释。
DOI：
10.1093/oxfordjournals.aje.a113142
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发表时间：
1981
影响因子：
5
通讯作者：
David G Clayton
中科院分区：
文献类型：
--
作者：
Michael Clarke;David G Clayton
设计围产期死亡前瞻性研究的难度使得病例对照研究成为一种首选方法。本文描述了在1976-1978年期间对85万人的围产期死亡进行的研究中，与危险因素的识别、病例的定义和计数以及活产控制措施的选择有关的特殊问题。出于可行性原因选择的对照选择方法产生了非代表性的对照样本。这是因为对照组被选为发生围产期死亡分娩的分娩地点的下一个活产，这导致了按分娩地点分层的样本。了解所有出生的分娩地点，就可以根据进行匹配的各阶层的相对权重进行校正。
The difficulty of designing prospective studies of perinatal death makes the case-control study a method of choice. The particular problems associated with the identification of risk factors, the definition and enumeration of cases, and the selection of live birth controls in such a study, undertaken on all perinatal deaths occurring in a population of 850,000 people during 1976-1978 are described. The method of control selection, chosen for reasons of feasibility, produced a nonrepresentative sample of controls. This was because controls were selected as the next live birth in the place of delivery where the perinatal death delivery occurred, which resulted in a sample stratified by place of delivery. Knowledge of the place of delivery of all births allowed a correction to be undertaken which was derived from the relative weights for the strata within which matching had occurred.