Cancer Risk and Mutational Patterns Following Organ Transplantation.
Cancer Risk and Mutational Patterns Following Organ Transplantation.
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DOI：
10.3389/fcell.2022.956334
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
医疗技术的快速发展和免疫抑制剂的广泛应用，大大提高了器官移植的成功率。然而，免疫抑制剂的使用大大增加了恶性肿瘤的发生率。随着肿瘤精准医学的前景和下一代测序技术的发展，高通量测序技术在临床肿瘤学研究中的应用越来越受到重视，主要应用于肿瘤的早期诊断和肿瘤相关基因的分析。所有世代的癌症都携带体细胞突变，同时，不同肿瘤之间的突变特征也有显著差异。对器官移植后患者的癌症基因组进行系统测序可以揭示暴露的癌细胞及其前体细胞的DNA损伤和修复过程。本文综述了高通量测序和有机类化合物在器官移植、肿瘤基因组突变模式等方面的应用，并提出了了解器官移植后肿瘤发生机制的新的研究策略。
The rapid development of medical technology and widespread application of immunosuppressive drugs have improved the success rate of organ transplantation significantly. However, the use of immunosuppressive agents increases the frequency of malignancy greatly. With the prospect of “precision medicine” for tumors and development of next-generation sequencing technology, more attention has been paid to the application of high-throughput sequencing technology in clinical oncology research, which is mainly applied to the early diagnosis of tumors and analysis of tumor-related genes. All generations of cancers carry somatic mutations, meanwhile, significant differences were observed in mutational signatures across tumors. Systematic sequencing of cancer genomes from patients after organ transplantation can reveal DNA damage and repair processes in exposed cancer cells and their precursors. In this review, we summarize the application of high-throughput sequencing and organoids in the field of organ transplantation, the mutational patterns of cancer genomes, and propose a new research strategy for understanding the mechanism of cancer following organ transplantation.
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影响因子：
120.7
作者：
Engels, Eric A.;Pfeiffer, Ruth M.;Fraumeni, Joseph F., Jr.;Kasiske, Bertram L.;Israni, Ajay K.;Snyder, Jon J.;Wolfe, Robert A.;Goodrich, Nathan P.;Bayakly, A. Rana;Clarke, Christina A.;Copeland, Glenn;Finch, Jack L.;Fleissner, Mary Lou;Goodman, Marc T.;Kahn, Amy;Koch, Lori;Lynch, Charles F.;Madeleine, Margaret M.;Pawlish, Karen;Rao, Chandrika;Williams, Melanie A.;Castenson, David;Curry, Michael;Parsons, Ruth;Fant, Gregory;Lin, Monica
通讯作者：
Lin, Monica
影响因子：
3
作者：
Cheung, Chi Yuen;Lam, Man Fai;Chau, Ka Foon
通讯作者：
Chau, Ka Foon
影响因子：
5.4
作者：
Chapman, Jeremy R.;Webster, Angela C.;Wong, Germaine
通讯作者：
Wong, Germaine
DOI：
10.1093/jnci/djaa078
发表时间：
2021-02-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
D'Arcy ME;Castenson D;Lynch CF;Kahn AR;Morton LM;Shiels MS;Pfeiffer RM;Engels EA
通讯作者：
Engels EA
影响因子：
1.9
作者：
Faride Rodriguez-Aguilar, Erika;Sastre, Lydia;Navasa, Miguel
通讯作者：
Navasa, Miguel