Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma
Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma
复制标题
DOI：
10.1177/0022034512467352
复制
发表时间：
2013-02-01
影响因子：
7.6
通讯作者：
D'Silva, N. J.
中科院分区：
文献类型：
--
作者：
Scanlon, C. S.;Van Tubergen, E. A.;D'Silva, N. J.
了解肿瘤细胞破坏表面上皮基底膜、侵袭和转移的过程对于开发头颈鳞状细胞癌（HNSCC）的新疗法至关重要。近年来，人们对上皮间质转化（EMT）在侵袭中的作用越来越感兴趣。 EMT 是描述从不活动的亲代上皮细胞发育为活动的间充质样细胞的过程。有 3 种已知的 EMT 类型可介导发育、伤口愈合和癌变。本综述总结了 HNSCC 进展背景下已知 EMT 生物标志物的研究。讨论的生物标志物来自多种蛋白质，包括细胞表面蛋白（E-钙粘蛋白、N-钙粘蛋白和整合素）、细胞骨架蛋白（α-平滑肌肌动蛋白、波形蛋白和 β-连环蛋白）、细胞外基质蛋白（胶原、纤连蛋白和层粘连蛋白）和转录因子（SNAIL1、SNAIL2、TWIST 和 LEF-1）。总体而言，这些研究结果表明 EMT 介导 HNSCC 进展。如果要开发新的抗 HNSCC 疗法来阻止 EMT 进展，则应该更清楚地定义与 HNSCC 相关的 EMT 标志物的机制作用。
An understanding of the process by which tumor cells destroy the basement membrane of the surface epithelium, invade, and metastasize is essential to the development of novel treatment of head and neck squamous cell carcinoma (HNSCC). In recent years, there has been increased interest in the role of epithelial-mesenchymal transition (EMT) in invasion. EMT is a process that describes the development of motile, mesenchymal-like cells from non-motile parent epithelial cells. There are 3 known types of EMT that mediate development, wound healing, and carcinogenesis. This review summarizes studies of known EMT biomarkers in the context of HNSCC progression. The biomarkers discussed come from a wide range of proteins, including cell-surface proteins (E-cadherin, N-cadherin, and Integrins), cytoskeletal proteins (alpha-Smooth Muscle Actin, Vimentin, and beta-catenin), extracellular matrix proteins (Collagens, Fibronectin, and Laminin), and transcription factors (SNAIL1, SNAIL2, TWIST, and LEF-1). Overall, the findings of these studies suggest that EMT mediates HNSCC progression. The mechanistic role of the EMT markers that have been associated with HNSCC should be more clearly defined if new anti-HNSCC therapies to block EMT progression are to be developed.