Metalloproteinases: a Functional Pathway for Myeloid Cells
Metalloproteinases: a Functional Pathway for Myeloid Cells
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DOI：
10.1128/microbiolspec.mchd-0002-2015
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发表时间：
2016-04-01
影响因子：
3.7
通讯作者：
Werb, Zena
中科院分区：
文献类型：
--
作者：
Chou, Jonathan;Chan, Matilda F.;Werb, Zena
髓样细胞在调节免疫、炎症和细胞外基质更新中具有不同的作用。为了完成这些任务，骨髓细胞携带大量的金属蛋白酶，包括基质金属蛋白酶和adamalysins。这些酶具有不同的底物库，因此参与介导蛋白水解级联、细胞迁移和细胞信号传导。金属蛋白酶的失调有助于致病过程，包括炎症、纤维化和癌症。金属蛋白酶在巨噬细胞融合过程中控制细胞骨架动力学和增强转录以促进抗病毒免疫方面也具有重要的非蛋白水解功能。这篇综述强调了金属蛋白酶对髓系细胞功能的不同贡献。
Myeloid cells have diverse roles in regulating immunity, inflammation, and extracellular matrix turnover. To accomplish these tasks, myeloid cells carry an arsenal of metalloproteinases, which include the matrix metalloproteinases and the adamalysins. These enzymes have diverse substrate repertoires, and are thus involved in mediating proteolytic cascades, cell migration, and cell signaling. Dysregulation of metalloproteinases contributes to pathogenic processes, including inflammation, fibrosis, and cancer. Metalloproteinases also have important nonproteolytic functions in controlling cytoskeletal dynamics during macrophage fusion and enhancing transcription to promote antiviral immunity. This review highlights the diverse contributions of metalloproteinases to myeloid cell functions.