PENETRATING KERATOPLASTY FOR HERPES-SIMPLEX KERATITIS
PENETRATING KERATOPLASTY FOR HERPES-SIMPLEX KERATITIS
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DOI：
10.1016/0002-9394(81)90522-5
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
DUNCAN, J
中科院分区：
文献类型：
--
作者：
FOSTER, CS;DUNCAN, J
对82例为治疗单纯疱疹性角膜炎而施行的穿透性角膜移植术进行了回顾性纵向队列研究。53例（65%）有广泛的角膜新生血管或基质溃疡和活动性眼内炎症，使这些病例的预后差。在分析时，只有32个移植物（39%）是透明的。活动性炎症、活动性溃疡、穿孔或广泛新生血管形成的患者成功率特别低。角膜移植术前穿孔的保守治疗非常成功（13只眼[85%]的11个透明移植物）。其他预后良好的类型包括平静眼的角膜水肿和瘢痕。对数据进行初步分析，以建立一个模型来预测单纯疱疹性角膜炎穿透性角膜移植术的结果。该模型以术前眼部状态和管理技术为术语。对模型的测试表明，样本中各组之间的结果存在显著差异。
A retrospective longitudinal cohort study of 82 penetrating keratoplasties performed to treat herpes simplex keratitis was conducted. In 53 cases (65%) there was extensive corneal neovascularization or stromal ulceration and active intraocular inflammation, making the prognosis in these cases poor. Only 32 grafts (39%) were clear at the time of analysis. Patients with active inflammation, active ulceration, perforation or extensive neovascularization had particularly poor success rates. Conservative management of perforation before keratoplasty was highly successful (11 clear grafts in 13 eyes [85%]). Other categories with a good prognosis included disciform edema and scarred corneas in quiet eyes. A preliminary analysis of the data was used to build a model to predict the outcome of penetrating keratoplasty in herpes simplex keratitis. The model used preoperative ocular status and management technique as its terms. Testing of the model showed that there were significant differences in outcome between the groups in the sample.