Exosomes in the lung cancer microenvironment: biological functions and potential use as clinical biomarkers.
Exosomes in the lung cancer microenvironment: biological functions and potential use as clinical biomarkers.
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肺癌微环境中的外泌体：生物学功能和作为临床生物标志物的潜在用途
DOI：
10.1186/s12935-021-01990-0
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发表时间：
2021-06-30
影响因子：
5.8
通讯作者：
Hua B
中科院分区：
文献类型：
--
作者：
Qi R;Zhao Y;Guo Q;Mi X;Cheng M;Hou W;Zheng H;Hua B
肺癌是世界上最常见的恶性肿瘤之一。然而，新兴的免疫疗法和靶向疗法继续显示出有限的功效。在寻找肺癌治疗的新靶点时，外泌体已成为研究的主要焦点。外泌体在肺癌的肿瘤微环境（TME）中起重要作用，并影响侵袭、转移和治疗反应。这篇综述描述了我们目前对TME中来自不同细胞的外泌体的释放的理解，外泌体对T/T细胞，骨髓源性抑制细胞，肿瘤相关巨噬细胞，树突状细胞和自然杀伤细胞的影响，以及外泌体在内皮-间充质转化，血管生成和癌症相关成纤维细胞中的作用。特别是，这篇综述侧重于外泌体在肺癌微环境中的潜在临床应用及其预后和诊断价值。
Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited efficacy. In the search for new targets for lung cancer treatment, exosomes have become a major focus of research. Exosomes play an important role in the tumour microenvironment (TME) of lung cancer and affect invasion, metastasis, and treatment responses. This review describes our current understanding of the release of exosomes derived from different cells in the TME, the effects of exosomes on T/Tregs, myeloid-derived suppressor cells, tumour-associated macrophages, dendritic cells, and natural killer cells, and the role of exosomes in the endothelial–mesenchymal transition, angiogenesis, and cancer-associated fibroblasts. In particular, this review focuses on the potential clinical applications of exosomes in the lung cancer microenvironment and their prognostic and diagnostic value.
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影响因子：
--
作者：
Gutkin A;Uziel O;Beery E;Nordenberg J;Pinchasi M;Goldvaser H;Henick S;Goldberg M;Lahav M
通讯作者：
Lahav M
影响因子：
5.2
作者：
Di Pace, Anna Laura;Tumino, Nicola;Moretta, Lorenzo
通讯作者：
Moretta, Lorenzo
影响因子：
21.3
作者：
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通讯作者：
Lyden D
DOI：
10.1073/pnas.1209414109
发表时间：
2012-07-31
影响因子：
11.1
作者：
Fabbri, Muller;Paone, Alessio;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
7.2
作者：
Berchem G;Noman MZ;Bosseler M;Paggetti J;Baconnais S;Le Cam E;Nanbakhsh A;Moussay E;Mami-Chouaib F;Janji B;Chouaib S
通讯作者：
Chouaib S