Magnitude and breadth of a nonprotective neutralizing antibody response in an efficacy trial of a candidate HIV-1 gp120 vaccine.
Magnitude and breadth of a nonprotective neutralizing antibody response in an efficacy trial of a candidate HIV-1 gp120 vaccine.
复制标题
DOI：
10.1086/654816
复制
发表时间：
2010-08-15
期刊：
影响因子：
--
通讯作者：
Montefiori DC
中科院分区：
文献类型：
--
作者：
Gilbert P;Wang M;Wrin T;Petropoulos C;Gurwith M;Sinangil F;D'Souza P;Rodriguez-Chavez IR;DeCamp A;Giganti M;Berman PW;Self SG;Montefiori DC
一种由人类免疫缺陷病毒1型亚基gp120蛋白组成的候选疫苗(AIDSVAX™B/B)此前被发现对疫苗抗原具有较强的抗体反应，但不具有保护性。在这项试验中，我们评估了中和抗体反应的幅度和广度。在两个独立的检测中，对高度敏感(第1级)和中等敏感(第2级)的HIV-1 B亚型毒株进行了中和抗体测定。疫苗接受者按性别、种族和感染HIV-1的高与低行为风险进行分层。大多数疫苗接受者对HIV-1MN和其他一级病毒的子集产生了强大的中和抗体反应。偶尔检测到对第二级病毒的弱中和活性。女性对第1级和第2级病毒的反应明显强于男性。种族和HIV-1感染的行为风险对反应没有显著影响。预先接种疫苗对感染后产生的中和抗体反应几乎没有影响。针对第2层病毒的总体中和抗体反应较弱，这与本试验中缺乏保护一致。这里报告的中和程度和广度应该有助于识别改进的疫苗。
A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein (AIDSVAX™ B/B) was found previously to be non-protective despite strong antibody responses against the vaccine antigens. We assessed the magnitude and breadth of neutralizing antibody responses in this trial. Neutralizing antibodies were measured against highly sensitive (tier 1) and moderately sensitive (tier 2) strains of HIV-1 subtype B in two independent assays. Vaccine recipients were stratified by gender, race and high versus low behavioral risk of HIV-1 acquisition. Most vaccine recipients mounted potent neutralizing antibody responses against HIV-1MN and a subset of other tier 1 viruses. Occasional weak neutralizing activity was detected against tier 2 viruses. The response against tier 1 and tier 2 viruses was significantly stronger in women than in men. Race and behavioral risk of HIV-1 acquisition had no significant effect on the response. Prior vaccination had little effect on the neutralizing antibody response that arose post infection. Weak overall neutralizing antibody responses against tier 2 viruses is consistent with a lack of protection in this trial. The magnitude and breadth of neutralization reported here should be useful for identifying improved vaccines.
登录
查看更多内容
DOI：
10.1073/pnas.0802203105
发表时间：
2008-05-27
影响因子：
11.1
作者：
Keele, Brandon F.;Giorgi, Elena E.;Shaw, George M.
通讯作者：
Shaw, George M.
影响因子：
3.7
作者：
Davis, Katie L.;Gray, Elin S.;Shaw, George M.
通讯作者：
Shaw, George M.
影响因子：
3.7
作者：
Berman, PW;Huang, W;Gregory, TJ
通讯作者：
Gregory, TJ
DOI：
10.1084/jem.20042510
发表时间：
2005-05-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Decker JM;Bibollet-Ruche F;Wei X;Wang S;Levy DN;Wang W;Delaporte E;Peeters M;Derdeyn CA;Allen S;Hunter E;Saag MS;Hoxie JA;Hahn BH;Kwong PD;Robinson JE;Shaw GM
通讯作者：
Shaw GM
影响因子：
5.4
作者：
Li, Ming;Salazar-Gonzalez, Jesus F.;Montefiori, David C.
通讯作者：
Montefiori, David C.