Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum
Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum
复制标题
适应压力暴露可通过增加肌浆网活性来防止过量 Ca2 对心脏产生心律失常和收缩作用
DOI：
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发表时间：
2005
影响因子：
9.5
通讯作者：
T. G. Sazontova
中科院分区：
文献类型：
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作者：
F. Z. Meerson;I. Malyshev;T. G. Sazontova
大鼠对重复短期应激暴露的适应在很大程度上防止了高浓度细胞外Ca2+对离体心脏的收缩和致心律失常作用。SR Ca2+泵功能效率的提高和Ca2+泵自溶阻力的显著增加被证明在这种效应中起主要作用。
SummaryAdaptation of rats to repcated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2+-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect.