Rheogenic and passive Na+ absorption by the proximal nephron.
Rheogenic and passive Na+ absorption by the proximal nephron.
复制标题
近端肾单位的流变和被动 Na 吸收。
DOI：
10.1146/annurev.ph.41.030179.001235
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发表时间：
1979
影响因子：
18.2
通讯作者：
T. E. Andreoli
中科院分区：
文献类型：
--
作者：
J. A. Schafer;T. E. Andreoli
本文综述了近年来哺乳动物近端肾单位吸收氯化钠的机制。大多数关于上皮细胞NaCl转运的争论来自H. H. Ussing和他的同事分析了无尾两栖类上皮细胞中的Na+通量。他们的唤起模式源于三个主要的考虑。Ussing（69）和Ussing & Zerahn（71）证明，净Na+转运与零电压短路电流相同，并且逆电化学梯度发生。然后Koefoed-Johnsen & Ussing（33）提出Na+在顶面被动进入细胞，并通过主动Na+ /K+交换泵在基底面主动转运出细胞。最后，Ussing和Windhager（70）提供了强有力的证据，表明上皮细胞中的耗散离子转运可能涉及细胞旁途径。应用于哺乳动物近端肾小管的Ussing范例还需要分析某些其他因素。在这方面特别重要的是：
This review summarizes recent considerations germane to the mecha nism(s) for NaCI absorption by the mammalian proximal nephron. Most arguments concerning epithelial NaCI transport derive from the hypotheses formulated by H. H. Ussing and his associates in their analysis of Na+ fluxes in anuran epithelia. Their evocative model derives from three major consid erations. Ussing (69) and Ussing & Zerahn (71) demonstrated that net Na+ transport was identical to the zero-voltage short-circuit current and occurred against an electrochemical gradient. Then Koefoed-Johnsen & Ussing (33) proposed that Na+ entered cells passively at apical surfaces and was actively transported out of cells at basolateral surfaces via an active Na+ /K+ exchange pump. Finally, Ussing & Windhager (70) provided strong evidence that dissipative ion transport in epithelia might involve a paracellular route. The application of Ussing's paradigm to the mamm alian proximal renal tubule also requires analysis of certain other factors. Of particular impor tance in this context are the following: