Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin
Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus alpha-hemolysin
复制标题
苦参碱减轻金黄色葡萄球菌α-溶血素所致牛乳腺上皮细胞损伤的作用
DOI：
10.24425/122610
复制
发表时间：
2018-01-01
影响因子：
0.8
通讯作者：
Zhou, X. Z.
中科院分区：
文献类型：
--
作者：
Feng, F.;Ma, W. W.;Zhou, X. Z.
以细菌毒力因子为靶点治疗宿主细菌感染是一种新的治疗方法。研究苦参碱对金黄色葡萄球菌（S。aureus）对牛乳腺上皮细胞（BMEC）的损伤作用。金黄色葡萄球菌α-溶血素。亚抑制浓度的苦参碱对溶血素的产生无剂量依赖性的抑制作用，苦参碱对S.金黄色葡萄球菌引起的BMEC损伤。结果表明，苦参碱的结构有可能作为开发治疗和预防奶牛乳房炎药物的基础结构。
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on alpha-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus alpha-hemolysin. Subinhibitory concentrations of matrine decreased the production of alpha-hemolysin in none dose-dependent it manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.