Three-dimensional structural and angiographic evaluation of foveal ischemia in diabetic retinopathy: method and validation.
Three-dimensional structural and angiographic evaluation of foveal ischemia in diabetic retinopathy: method and validation.
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DOI：
10.1364/boe.10.003522
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发表时间：
2019-06
影响因子：
3.4
通讯作者：
Bingjie Wang;Acner Camino;Shaohua Pi;Yukun Guo;Jie Wang;David Huang;T. Hwang;Yali Jia
中科院分区：
文献类型：
--
作者：
Bingjie Wang;Acner Camino;Shaohua Pi;Yukun Guo;Jie Wang;David Huang;T. Hwang;Yali Jia
光学相干断层扫描血管造影 (OCTA) 使我们能够无创地研究黄斑中心凹缺血，这是糖尿病视网膜病变 (DR) 的一个关键特征。然而，正常人群中中心凹无血管区（FAZ）的大小存在显着差异，妨碍了对毛细血管脱落导致的 FAZ 病理性扩大的客观评估。基于正常眼中 FAZ 与神经节细胞复合体 (GCC) 厚度之间的关系，我们在结构 OCT 上定义了理论基线 FAZ (tbFAZ)，并在正常眼和糖尿病眼中同时采集的 OCTA 上测量了其附近的 2D 和 3D 血管密度。我们发现基于结构的 tbFAZ 是识别中心凹缺血的可靠参考，并且 3D 血管密度比 2D 方法更有效地证明缺血。所提出的 3D para-FAZ 血管密度与 DR 严重程度密切相关，并且可能是一种有用的诊断生物标志物，尤其是在 DR 的早期阶段。
Optical coherence tomography angiography (OCTA) allows us to noninvasively investigate foveal ischemia, a key feature of diabetic retinopathy (DR). However, the sizes of the foveal avascular zone (FAZ) have a significant variation in normal population, preventing the objective assessment of pathological enlargement of FAZ due to capillary dropout. Based on the relationship between FAZ and ganglion cell complex (GCC) thickness in normal eyes, we defined a theoretical baseline FAZ (tbFAZ) on structural OCT and measured 2D and 3D vessel density in its vicinity on the simultaneously acquired OCTA in normal and diabetic eyes. We found that the structure-based tbFAZ was a reliable reference to identify foveal ischemia and that the 3D vessel density demonstrated ischemia more effectively than the 2D method. The proposed 3D para-FAZ vessel density correlates well with DR severity and potentially is a useful diagnostic biomarker, especially in the early stages of DR.