PASSIVE PROPAGATION OF LTD TO STRATUM ORIENS-ALVEUS INHIBITORY NEURONS MODULATES THE TEMPOROAMMONIC INPUT TO THE HIPPOCAMPAL CA1 REGION
PASSIVE PROPAGATION OF LTD TO STRATUM ORIENS-ALVEUS INHIBITORY NEURONS MODULATES THE TEMPOROAMMONIC INPUT TO THE HIPPOCAMPAL CA1 REGION
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DOI：
10.1016/0896-6273(95)90071-3
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发表时间：
1995-07-01
期刊：
影响因子：
16.2
通讯作者：
MCBAIN, CJ
中科院分区：
文献类型：
--
作者：
MACCAFERRI, G;MCBAIN, CJ
兴奋性突触活动水平层方向肺泡中间神经元（OAIs）是由CA 1锥体细胞的经常性侧支驱动，并强烈影响的协议，引发这些主要神经元的突触可塑性。在谢弗侧支-CA 1锥体神经元突触中LTD的诱导导致放射层诱发的兴奋性突触反应对OAI的被动下调。此外，我们表明，颞氨输入的强度的CA 1锥体神经元远端树突的OAI活性调节。LTD到OAI的被动传播因此解除了直接内嗅皮层-CA 1输入的抑制，导致CA 1锥体神经元通过不需要激活三突触通路的机制增强兴奋。
Excitatory synaptic activity in horizontal stratum oriens-alveus interneurons (OAIs) is driven by the recurrent collaterals of CA1 pyramidal cells and is strongly influenced by protocols that elicit synaptic plasticity in these principal neurons. Induction of LTD in the Schaffer collateral-CA1 pyramidal neuron synapse causes a passive down-regulation of stratum radiatum-evoked excitatory synaptic responses onto OAIs. In addition, we show that the strength of the temporoammonic input to the CA1 pyramidal neuron distal dendrites is regulated by OAI activity. The passive propagation of LTD to OAIs consequently disinhibits the direct entorhinal cortex-CA1 input, resulting in an enhanced excitation of CA1 pyramidal neurons by a mechanism not requiring activation of the trisynaptic pathway.