Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases.
Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases.
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DOI：
10.12688/f1000research.10397.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ho GT
中科院分区：
文献类型：
--
作者：
Boyapati RK;Tamborska A;Dorward DA;Ho GT
线粒体 DNA (mtDNA) 与细菌 DNA 有许多相似之处，因为它们具有共同的祖先。越来越多的证据表明，线粒体DNA是一种有效的危险信号，可以被先天免疫系统识别，并可以直接调节炎症反应。在人类中，循环 mtDNA 升高见于创伤和脓毒症等严重组织损伤的情况，并且越来越多地出现在脂肪性肝炎和系统性红斑狼疮等慢性器官特异性和全身性疾病中。在这篇综述中，我们研究了目前对 mtDNA 介导的炎症的理解，以及调节线粒体稳态和 mtDNA 释放的机制如何代表许多人类炎症疾病中令人兴奋且先前未被充分认识的重要因素，从而提供许多新的转化机会。
Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger signal that is recognised by the innate immune system and can directly modulate the inflammatory response. In humans, elevated circulating mtDNA is found in conditions with significant tissue injury such as trauma and sepsis and increasingly in chronic organ-specific and systemic illnesses such as steatohepatitis and systemic lupus erythematosus. In this review, we examine our current understanding of mtDNA-mediated inflammation and how the mechanisms regulating mitochondrial homeostasis and mtDNA release represent exciting and previously under-recognised important factors in many human inflammatory diseases, offering many new translational opportunities.