Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.
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DOI：
10.1016/j.matbio.2015.02.003
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Schaefer L
中科院分区：
文献类型：
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作者：
Iozzo RV;Schaefer L
我们提供了一个全面的分类的蛋白聚糖基因家族和各自的蛋白质核心。这种更新的命名法基于三个标准：细胞和亚细胞位置，整体基因/蛋白质同源性，以及在各自蛋白质核心内利用特定蛋白质模块。这三个签名被用来设计四个主要类别的蛋白聚糖不同的形式和功能：细胞内，细胞表面，细胞周围和细胞外蛋白聚糖。拟议的命名法包括43个不同的蛋白聚糖编码基因和许多选择性剪接变体。这四种蛋白聚糖家族的生物学功能在发育、癌症和血管生成以及它们的表达异常的各种获得性和遗传性疾病中被严格评估。
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.