Consumption of High-Oleic Acid Ground Beef Increases HDL-Cholesterol Concentration but Both High- and Low-Oleic Acid Ground Beef Decrease HDL Particle Diameter in Normocholesterolemic Men
Consumption of High-Oleic Acid Ground Beef Increases HDL-Cholesterol Concentration but Both High- and Low-Oleic Acid Ground Beef Decrease HDL Particle Diameter in Normocholesterolemic Men
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DOI：
10.3945/jn.110.136085
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发表时间：
2011-06-01
影响因子：
4.2
通讯作者：
Smith, Stephen B.
中科院分区：
文献类型：
--
作者：
Gilmore, L. Anne;Walzem, Rosemary L.;Smith, Stephen B.
在本实验室先前研究结果的基础上，本研究验证了高MUFA和低SEA的碎牛肉会增加HDL-胆固醇（HDL-C）浓度和LDL颗粒直径的假设。在一项交叉饮食干预中，27名自由生活的胆固醇水平正常的男性完成了治疗，其中5个114克碎牛肉饼/周，为期5周，中间有4周的洗脱期。肉饼含有24%的总脂肪，MUFA：SFA的比例为0.71（低MUFA，来自牧场饲养的牛）或1.10（高MUFA，来自谷物饲养的牛）。与低MUFA绞细牛肉相比，高MUFA绞细牛肉提供了3.21 g的18：1（n-9），1.26 g的18：0，0.89 g的16：0和0.36 g的18：1（反式）脂肪酸。两种绞细牛肉干预均降低了血浆胰岛素和HDL 2和HDL 3颗粒直径，并增加了血浆18：0和20：4（n-6）（所有P 0.50），表明这些指标的降低未得到协调调节。这些数据表明，饮食牛肉干预对心血管疾病的风险因素有影响，这些风险因素是独立的（胰岛素，HDL直径）和依赖的（HDL-C）牛肉脂肪酸组成。J.营养141：1188-1194，2011.
On the basis of previous results from this laboratory, this study tested the hypothesis that ground beef high in MUFA and low in SEA would increase the HDL-cholesterol (HDL-C) concentration and LDL particle diameter. In a crossover dietary intervention, 27 free-living normocholesterolemic men completed treatments in which five 114-g ground beef patties/wk were consumed for 5 wk with an intervening 4-wk washout period. Patties contained 24% total fat with a MUFA:SFA ratio of either 0.71 (low MUFA, from pasture-fed cattle) or 1.10 (high MUFA, from grain-fed cattle). High-MUFA ground beef provided 3.21 g more 18:1(n-9), 1.26 g less 18:0, 0.89 g less 16:0, and 0.36 g less 18:1 (trans) fatty acids per patty than did the low-MUFA ground beef. Both ground beef interventions decreased plasma insulin and HDL2 and HDL3 particle diameters and increased plasma 18:0 and 20:4(n-6) (all P 0.50), indicating that reductions in these measures were not coordinately regulated. The data indicate that dietary beef interventions have effects on risk factors for cardiovascular disease that are independent (insulin, HDL diameters) and dependent (HDL-C) on beef fatty acid composition. J. Nutr. 141: 1188-1194, 2011.