The human false vocal folds - an analysis of antimicrobial defense mechanisms
The human false vocal folds - an analysis of antimicrobial defense mechanisms
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DOI：
10.1007/s00429-002-0255-8
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发表时间：
2002-07-01
期刊：
影响因子：
--
通讯作者：
Paulsen, F
中科院分区：
文献类型：
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作者：
Kutta, H;Steven, P;Paulsen, F
炎症过程通常会导致喉部的病理改变。假性声带的润湿作用经常被描述。到目前为止，我们对假声带对病原体的保护作用知之甚少。本研究分析了假声带的结构及其与抗菌防御机制的关系。应用组织学、组织化学和免疫组织化学方法对34具身体的假声带进行了研究。浆膜粘液腺与皱褶的上皮细胞和杯状细胞一起合成一层复杂的粘液层。在所有研究的样品中，这一层含有碳水化合物，包括N-乙酰氨基葡萄糖、N-乙酰氨基半乳糖、半乳糖、甘露糖、岩藻糖和唾液酸。此外，在这些结构中还发现了乳铁蛋白、溶菌酶、α和β防御素等抗菌肽。IGA是由假声带中的浆细胞产生的，通常整合在分泌产物中。合成的粘蛋白、抗菌肽和免疫球蛋白形成了一种特殊的保护物质，主要在真正的声带皱折处分泌。在这里，这一层的作用是润滑真正的声带，在发声过程中产生积极的功能后果。此外，保护层与免疫活性细胞一起，似乎在抗原防御和防止病原体入侵方面发挥了主要作用。
Inflammatory processes often lead to pathologic changes in the area of the larynx. A moistening function of the false vocal folds has been described frequently. Up to now we have little knowledge of the role of the false vocal folds in protection against pathogenic agents. The present study analyzes the structures of the false vocal folds in their relations to antimicrobial defense mechanisms. Investigations were performed on false vocal folds of larynges from 34 cadavers using histologic, histochemical and immunohistochemical methods. Seromucous glands, together with epithelial and goblet cells of the folds, synthesize a complex mucus layer. In all of the investigated samples this layer contains carbohydrates including N-acetyl-glucosamine, N-acetyl-galactosamine, galactose, mannose, fucose, and sialic acids. Furthermore, antimicrobial peptides like lactoferrin, lysozyme, alpha and beta defensins are also found in these structures. IgA, produced by plasma cells in the false vocal folds, is frequently integrated in the secretory product. Synthesized mucins, antimicrobial peptides and immunoglobulins form a specialized protective substance that is secreted mainly at the true vocal folds. Here the layer functions to lubricate the true vocal folds, resulting in positive functional consequences during vocal production. Moreover, together with immunocompetent cells, the protective layer seems to play a major role in antigen defense and prevents invasion of pathogenic agents.