Glyburide Transport Across the Human Placenta
Glyburide Transport Across the Human Placenta
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DOI：
10.1097/aog.0000000000000672
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发表时间：
2015-03-01
影响因子：
7.2
通讯作者：
Koren, Gideon
中科院分区：
文献类型：
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作者：
Schwartz, Rachelle A.;Rosenn, Barak;Koren, Gideon
目的：评估妊娠期糖尿病 (GDM) 女性中格列本脲经胎盘转移的程度。方法：对患有 GDM 的女性进行格列本脲治疗的前瞻性观察性研究。入院时记录格列本脲的剂量和最后一次给药的时间。分娩后立即采集母体和脐静脉血样本，并通过高效液相色谱-质谱法测定格列本脲的浓度，检测限为 0.25 ng/mL。 结果：对 19 名患者进行了分析。母亲每日平均总格列本脲剂量为每天 6.6 +/- 6.3 mg，最后一次给药和取样之间的平均时间为 13.3 +/- 6.5 小时。出生时母体血清格列本脲平均水平为 15.4 +/- 20.8 ng/mL，而脐带格列本脲平均水平为 7.5 +/- 8.2 ng/mL，显示出统计相关性 (r(2)=0.72，P
OBJECTIVE: To estimate the magnitude of transplacental transfer of glyburide in women with gestational diabetes mellitus (GDM).METHODS: A prospective, observational study was conducted on women with GDM on glyburide therapy. On delivery admission, the glyburide dose and time of last dose were recorded. Immediately postdelivery, maternal and umbilical venous blood samples were obtained and the concentrations of glyburide were determined by high-performance liquid chromatography-mass spectrometry with a limit of detection of 0.25 ng/mL.RESULTS: Nineteen patient dyads were analyzed. The mean total daily maternal glyburide dose was 6.6 +/- 6.3 mg per day and the mean time between last dose and sampling was 13.3 +/- 6.5 hours. The mean maternal serum glyburide level at birth was 15.4 +/- 20.8 ng/mL, whereas the mean umbilical glyburide level was 7.5 +/- 8.2 ng/mL, which showed a statistical correlation (r(2)=0.72, P