The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
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DOI：
10.1007/s10654-020-00662-z
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发表时间：
2020-07-23
影响因子：
13.6
通讯作者：
Duijts, Liesbeth
中科院分区：
文献类型：
--
作者：
Jaddoe, Vincent W. V.;Felix, Janine F.;Duijts, Liesbeth
早期生活是改善整个生命周期健康的重要机会之窗。越来越多的证据表明，在生命早期暴露于不利的压力源会导致发育适应，这随后会影响以后的生活中的疾病风险。此外，地理、社会经济和种族差异与早年以来的健康不平等有关。为了应对这些重大的公共卫生挑战，在过去30年里建立了许多欧洲孕期和儿童期队列。这些队列的大量数据导致了重要的新的生物学见解，并从早期生命开始对健康产生了重要影响。通过合并来自不同队列的数据，可以进一步增加这些队列及其数据的影响。结合数据将有可能确定较小的影响估计，并有机会更好地确定跨国家生命周期导致疾病的风险群体和风险因素。此外，它还使研究能够更好地对生命过程健康轨迹进行因果理解和建模。由Horizon 2020资助的生命周期项目建立的欧盟儿童队列网络汇集了19个怀孕和儿童队列，包括超过25万名儿童和他们的父母。一大组变量在这些队列中得到了协调和标准化。协调后的数据保存在每个机构内，外部研究人员可以通过一个共享的联合数据分析平台，使用以R为基础的平台DataSHIELD获取这些数据，该平台考虑到了相关的国家和国际数据条例。欧盟儿童群体网络具有开放的特点。数据统一和建立数据分析平台的所有协议都可在网上查阅。欧盟儿童队列网络为研究人员创造了在生命周期项目持续时间内和之后使用来自不同队列的数据的巨大机会。它还为在大型研究基础设施中使用个人级别的数据进行协作研究提供了一种新的模式。生命周期项目将把使用欧盟儿童队列网络的研究结果转化为有针对性的预防战略建议，通过优化当代和未来几代人的生命早期阶段来改善他们的健康轨迹。
Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.