A METHOD FOR MEASURING THE NON-RANDOM BIAS OF A CODON USAGE TABLE
A METHOD FOR MEASURING THE NON-RANDOM BIAS OF A CODON USAGE TABLE
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DOI：
10.1093/nar/12.24.9567
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发表时间：
1984-01-01
影响因子：
14.9
通讯作者：
BOSWELL, DR
中科院分区：
文献类型：
--
作者：
MCLACHLAN, AD;STADEN, R;BOSWELL, DR
我们描述了一种新的统计方法来衡量偏见的密码子使用表的基因。检验基于多项式和泊松分布。该方法用于扫描DNA序列和测量密码子偏好的强度。大肠大肠杆菌中，我们表明密码子偏好的强度与基因表达水平有关。该方法还可用于比较碱基三联体频率与从碱基组合物预期的那些。第二种类型的密码子偏好性测试可用于区分编码区和非编码区。
We describe a new statistical method for measuring bias in the codon usage table of a gene. The test is based on the multinomial and Poisson distributions. The method is used to scan DNA sequences and measure the strength of codon preference. For E. Coli we show that the strength of codon preference is related to levels of gene expression. The method can also be used to compare base triplet frequencies with those expected from the base composition. This second type of codon bias test is useful for distinguishing coding from non-coding regions.