Synthesis, Characterization, and Study of Drug Release Properties of Curcumin from Polycaprolactone /Organomodified Montmorillonite Nanocomposite
Synthesis, Characterization, and Study of Drug Release Properties of Curcumin from Polycaprolactone /Organomodified Montmorillonite Nanocomposite
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DOI：
10.1007/s12247-016-9253-x
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发表时间：
2016-12-01
影响因子：
2.6
通讯作者：
Agrawal, Yadvendra K.
中科院分区：
文献类型：
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作者：
Bakre, Lateef G.;Sarvaiya, Jayrajsinh I.;Agrawal, Yadvendra K.
采用纳米沉淀法制备了姜黄素/聚己内酯（PCL）纳米复合材料，并对其粒径、zeta电位和包封率进行了表征。扫描电子显微镜（SEM）和差示扫描量热法（DSC）测量的纳米粒子进行。结果表明，姜黄素纳米粒表面光滑、分散性好，粒径范围为155 ~ 206.5 nm，多分散指数较低（ae0.37），呈圆形，分散性较好。含有MMT的制剂比不含MMT的制剂具有更高的包封效率和药物负载。DSC分析表明纳米颗粒的组分之间没有潜在的相互作用。体外数据的分析表明，幂律最好地描述了释放机制，并提出了非菲克溶胀控制的药物释放。在制剂中，在第6小时发现60- 75%的初始突释，然后是更持续的释放。研究结果表明，将姜黄素引入到PCL/CTAB-MMT纳米粒中，可以改善药物的释放，为进一步提高姜黄素的抗肿瘤活性提供了一种有效的途径。
This study aims to intercalate polycaprolactone (PCL)/curcumin nanocomposite in the interlayer spaces of montmorillonite clay (MMT) modified with n-cetyl-N,N,N-trimethylammonium bromide (CTAB) for improved drug release.Curcumin-loaded polycaprolactone/organoclay nanoparticles prepared by nanoprecipitation method were characterized by determining the size, zeta potentials, and encapsulation efficiency. Scanning electron microscopy (SEM) and differential scanning calorimetry (DSC) measurements of the nanoparticles were performed. The data obtained from in vitro drug release studies were fitted into different drug release models, and the mechanism of drug release was determined.Result shows that the curcumin nanoparticles are round, discrete, and smooth in surface morphology, within the 155-206.5-nm size range, and have fairly low polydispersity index (ae0.37). Formulations containing MMT have higher encapsulation efficiency and drug loading than formulations without MMT. DSC analysis suggests no potential interaction between the components of the nanoparticles. Analysis of the in vitro data reveals that the power law best describes the release mechanism and suggests a non-Fickian swelling-controlled drug release. An initial burst of 60-75 % release was found at the sixth hour in the formulations and then a more sustained release afterwards. Formulations with higher MMT concentration showed slower drug release when compared with formulations with lower MMT concentration.This study suggests that the incorporation of curcumin into PCL/CTAB-MMT nanoparticles could result in improved drug release and also provided an effective way to further improve the antitumor activity of curcumin through the nanodrug delivery system.