Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: An immunohistochemical study
Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: An immunohistochemical study
复制标题
DOI：
10.1006/clin.1996.0007
复制
发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Holthofer, H
中科院分区：
文献类型：
--
作者：
Temonen, M;Mustonen, J;Holthofer, H
普马拉汉坦病毒引起的肾病流行（NE）是斯堪的纳维亚半岛、俄罗斯欧洲和巴尔干地区急性可逆性肾衰竭的重要原因。肾组织病理学的特征性表现是急性肾小管间质性肾炎。轻度至大量蛋白尿、血尿和血清肌酐水平升高是典型症状。NE型肾衰竭的发病机制尚不完全清楚。因此，我们研究了急性肾病时肾脏的浸润细胞群及细胞因子和生长因子的局部表达。8例肾活检的组织学和免疫组织学研究结果显示淋巴细胞、浆细胞、单核/巨噬细胞和多形核白细胞轻度至中度间质浸润，主要是嗜酸性粒细胞和中性粒细胞。肿瘤坏死因子- α转化生长因子- β和血小板衍生生长因子在相同部位的表达增加，主要在远端肾元的小管周围区域。同时，在相同的位置也可以看到内皮粘附分子ICAM-1、VCAM和PECAM的表达。微管的光镜变化是常见的。有趣的是，尽管经常有大量的短暂性蛋白尿，但在NE肾的肾小球中未见明显变化。肾脏活检中未发现普马拉病毒的证据。(C) 1996学术出版社有限公司
Puumala hantavirus-induced nephropathia epidemica (NE) is an important cause for an acute reversible renal failure in Scandinavia, European Russia, and the Balkans. The characteristic histopathological renal finding is an acute tubulointerstitial nephritis. Mild to massive proteinuria, hematuria, and a rise in the serum creatinine level are typically seen. The pathogenetic mechanisms of NE kidney failure are incompletely understood. Therefore we studied the infiltrating cell populations and local expression of cytokines and growth factors in the kidney during the acute disease. Results of the histological and immunohistological studies of eight kidney biopsies show mild to moderate interstitial infiltration of lymphocytes, plasma cells, monocytes/macrophages, and polymorphonuclear leukocytes, mainly eosinophilic granulocytes and neutrophils. An increased expression of the cytokines tumor necrosis factor-alpha transforming growth factor-beta, and platelet-derived growth factor was seen at the same sites mainly in the peritubular area of the distal nephron. Concomitantly also at the same locations expression of the endothelial adhesion molecules ICAM-1, VCAM, and PECAM was seen. Light microscopic changes in tubuli were common. Interestingly, despite the often massive transient proteinuria, no marked changes were seen in the glomeruli of NE kidneys. No evidence of Puumala virus was found in the kidney biopsies. (C) 1996 Academic Press Inc.