Elevated stress sensitivity in corticotropin-releasing factor receptor 2 deficient mice decreases maternal, but not intermale aggression
Elevated stress sensitivity in corticotropin-releasing factor receptor 2 deficient mice decreases maternal, but not intermale aggression
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DOI：
10.1016/j.bbr.2004.11.026
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发表时间：
2005-05-07
影响因子：
2.7
通讯作者：
D'Anna, KL
中科院分区：
文献类型：
--
作者：
Gammie, SC;Hasen, NS;D'Anna, KL
母性攻击是哺乳期雌性对入侵者的一种攻击形式，对后代的防御至关重要。在哺乳期，恐惧和焦虑减少，中枢神经系统对焦虑神经肽、促肾上腺皮质激素释放因子（CRF）的反应较低，中枢注射CRF可抑制母体的攻击行为。总之，这些以前的研究结果表明，减少CRF神经传递在哺乳期支持正常的母亲的侵略性表达。最近的研究表明，CRF受体2（CRFR2）缺陷的小鼠表现出增加的焦虑样行为，具有过敏性应激反应，并过度产生CRF。在这项研究中，我们研究了野生型（WT）和CRFR2缺陷小鼠的母体和雄性间的攻击。CRFR2突变小鼠在产后第4天相对于WT小鼠在表现出攻击性的百分比、平均攻击次数和攻击性遭遇的平均时间方面表现出显著的母体攻击性缺陷。然而，嗅雄性入侵者的时间，小狗检索，小狗的数量，和性能的高架十字迷宫基因型之间是相似的。相比之下，在连续三个测试日的任何一个测试日，不同基因型之间的雄性间攻击行为在任何指标上都没有差异。对于这两种形式的侵略没有网站的攻击入侵者不同的基因型。两者合计，结果表明，在压力敏感性和CRF的敲除（KO）小鼠的过度生产的差异，特别是影响母亲，但不intermale侵略。(c)2004 Elsevier B.V.保留所有权利。
Maternal aggression is a form of aggression towards intruders by lactating females that is critical for defense of offspring. During lactation, fear and anxiety are reduced, the CNS is less responsive to the anxiogenic neuropeptide, corticotropin-releasing factor (CRF), and central injections of CRF inhibit maternal aggression. Together, these previous findings suggest that decreased CRF neurotransmission during lactation supports normal maternal aggression expression. Recent work indicates that mice deficient in CRF receptor 2 (CRFR2) display increased anxiety-like behaviors, have a hypersensitive stress response, and overproduce CRF. In this study, we examined both maternal and intermale aggression in wild-type (WT) and CRFR2-deficient mice. CRFR2-mutant mice exhibited significant deficits in maternal aggression on postpartum Day 4 relative to WT mice in terms of percentage displaying aggression, mean number of attacks, and mean time in aggressive encounters. However, time sniffing male intruder, pup retrieval, number of pups, and performance on the elevated plus maze were similar between genotypes. In contrast, intermale aggression did not differ between genotype in any measure on any of three consecutive test days. For neither form of aggression did sites of attacks on the intruder differ between genotype. Taken together, the results suggest that differences in stress sensitivity and the overproduction of CRF of the knockout (KO) mice specifically affects maternal, but not intermale aggression. (c) 2004 Elsevier B.V. All rights reserved.