Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion
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DOI：
10.1038/ni1048
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发表时间：
2004-04-01
影响因子：
30.5
通讯作者：
Liu, YJ
中科院分区：
文献类型：
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作者：
Watanabe, N;Hanabuchi, S;Liu, YJ
T细胞动态平衡是维持外周T细胞池大小的自我调节过程。尽管树突状细胞(DC)似乎在T细胞稳态中起重要作用，但DC介导的T细胞稳态的分子调控尚不清楚。我们发现，胸腺基质淋巴生成素(TSLP)激活的人树突状细胞(DC)诱导了依赖于自身肽主要组织相容性复合体的自体CD4(+)T细胞群的强劲扩张。增殖中的T细胞采用并维持中枢记忆多克隆表型，可分化为辅助性T细胞1型或2型效应细胞。这些结果，结合TSLP在粘膜淋巴组织和胸腺上皮细胞中的表达，表明TSLP参与了DC介导的CD4(+)T细胞的动态平衡。
T cell homeostasis is a self-regulating process for maintaining the size of the peripheral T cell pool. Although dendritic cells (DCs) seem to be important in T cell homeostasis, the molecular regulation of DC-mediated T cell homeostasis is unknown. We show that human DCs activated by thymic stromal lymphopoietin (TSLP) induced a robust expansion of autologous CD4(+) T cell populations, which depended on self peptide-major histocompatibility complex. The proliferating T cells adopted and maintained a central memory polyclonal phenotype and could differentiate into T helper type 1 or type 2 effector cells. These results, together with findings of TSLP expression in epithelial cells of mucosal lymphoid tissues and thymus, indicate that TSLP is involved in DC-mediated CD4(+) T cell homeostasis.