Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.
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DOI：
10.1177/1535370216681549
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Kell DB
中科院分区：
文献类型：
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作者：
Pretorius E;Akeredolu OO;Soma P;Kell DB
我们回顾的证据表明，感染性病原体，包括那些成为宿主内的休眠，有一个主要的作用，发挥在类风湿性关节炎的病因和炎症，这是它的标志。这特别是因为它们可以产生交叉反应性（自身）抗原，以及强效的炎症因子，如脂多糖，其本身可以催化进一步的炎症反应，包括通过β-淀粉样蛋白形成。一系列的可观察性共存于许多慢性炎症性疾病以及类风湿性关节炎。它们包括铁失调、高凝、宿主红细胞的异常形态和微粒形成。铁的失调可能是负责周期性的再生长和复苏的休眠细菌，伴随着炎原的生产。目前的系统生物学分析受益于“连贯性”的哲学思想，它反映了这样一个原则，即如果一系列表面上不相关的发现被汇集到一个自洽的叙述中，那么这种叙述就会得到加强。因此，我们提供了一个连贯的和可测试的叙述，主要参与（往往休眠）细菌类风湿关节炎。
We review the evidence that infectious agents, including those that become dormant within the host, have a major role to play in much of the etiology of rheumatoid arthritis and the inflammation that is its hallmark. This occurs in particular because they can produce cross-reactive (auto-)antigens, as well as potent inflammagens such as lipopolysaccharide that can themselves catalyze further inflammagenesis, including via β-amyloid formation. A series of observables coexist in many chronic, inflammatory diseases as well as rheumatoid arthritis. They include iron dysregulation, hypercoagulability, anomalous morphologies of host erythrocytes, and microparticle formation. Iron dysregulation may be responsible for the periodic regrowth and resuscitation of the dormant bacteria, with concomitant inflammagen production. The present systems biology analysis benefits from the philosophical idea of “coherence,” that reflects the principle that if a series of ostensibly unrelated findings are brought together into a self-consistent narrative, that narrative is thereby strengthened. As such, we provide a coherent and testable narrative for the major involvement of (often dormant) bacteria in rheumatoid arthritis.