ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis.
ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis.
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DOI：
10.1097/moh.0000000000000580
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发表时间：
2020-05
影响因子：
3.2
通讯作者：
Suarez, Yajaira
中科院分区：
文献类型：
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作者：
Fernandez-Hernando, Carlos;Suarez, Yajaira
自2000年首次发现血管生成素样蛋白4（Angiopoetin-like 4，ANGPTL4）以来，ANGPTL4在脂质代谢和血管生物学的不同方面的参与已成为一个重要的研究领域。本文就ANGPTL4在调节代谢和非代谢功能中的作用及其在脂质代谢和血管功能障碍等方面的意义作一综述。ANGPTL4是一种分泌型糖蛋白，在脂质代谢中具有生理作用，主要在脂肪组织和肝脏中表达。ANGPTL4抑制脂蛋白脂肪酶的活性，从而促进循环甘油三酯水平的增加。因此，ANGPTL4已被高度审查为潜在的治疗靶点。ANGPTL4进一步参与肿瘤发生、血管生成、血管通透性和干细胞调节，这为使用ANGPTL4作为其他病理生理条件的潜在治疗靶点打开了新的机会。进一步确定ANGPTL4调节回路并定义介导其生物学效应的特定分子事件仍然是未来基于ANGPTL4的治疗应用在不同疾病环境中的关键。ANGPTL4在控制细胞特异性功能中的许多新的和未预料到的作用将有助于临床医生和研究人员开发潜在的治疗应用。
Since the first discovery of Angiopoetin-like 4 (ANGPTL4) in 2000, the involvement of ANGPTL4 in different aspects of lipid metabolism and vascular biology has emerged as an important research field. In this review, we summarize the fundamental roles of ANGPTL4 in regulating metabolic and non-metabolic functions and their implication lipid metabolism and with several aspects vascular function and dysfunction. ANGPTL4 is a secreted glycoprotein with a physiological role in lipid metabolism and a predominant expression in adipose tissue and liver. ANGPTL4 inhibits the activity of lipoprotein lipase and thereby promotes an increase in circulating triglyceride levels. Therefore, ANGPTL4 has been highly scrutinized as a potential therapeutic target. Further involvement of ANGPTL4 has been shown to occur in tumorigenesis, angiogenesis, vascular permeability and stem cell regulation, which and open new opportunities of using ANGPTL4 as potential therapeutic targets for other pathophysiological conditions. Further determination of ANGPTL4 regulatory circuits and defining specific molecular events that mediate its biological effects remains key to future ANGPTL4-based therapeutic applications in different disease settings. Many new and unanticipated roles of ANGPTL4 in the control of cell-specific functions will assist clinicians and researchers in developing potential therapeutic applications.