Effect of photofunctionalization on fluoride-treated nanofeatured titanium
Effect of photofunctionalization on fluoride-treated nanofeatured titanium
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DOI：
10.1177/0885328213501566
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发表时间：
2014-04-01
影响因子：
2.9
通讯作者：
Ogawa, Takahiro
中科院分区：
文献类型：
--
作者：
Ikeda, Takayuki;Hagiwara, Yoshiyuki;Ogawa, Takahiro
本研究的目的是评估紫外线处理（称为光功能化）对喷砂和氢氟酸处理组合产生的纳米钛的生物和骨整合能力的影响。在磁盘和圆柱体形式的钛样品进行光功能化处理与紫外光15分钟。纳米功能化后的表面从疏水性转化为超亲水性。在大鼠模型中，通过生物力学推入试验测量的骨整合强度，在愈合的早期（第2周）和晚期（第4周），光功能化种植体比未处理种植体分别强2.2和2.3倍，这意味着光功能化不仅加速了骨整合，而且增加了骨整合的程度。使用骨髓来源的成骨细胞的培养研究表明，成骨细胞的附着，扩散和功能表型，如碱性磷酸酶活性和矿化，在光功能化钛显着增加。总之，光功能化显著增加了纳米钛表面的生物学和骨整合能力。鉴于文献中已证实的对微特征表面的有效性，光功能化可能提供一种新颖且实用的途径，以进一步提高具有微米至纳米特征的各种表面形态的植入物的骨整合能力。
The objective of this study was to evaluate the effect of ultraviolet light treatment, known as photofunctionalization, on the biological and osseointegration capability of nanofeatured titanium created by a combination of sandblasting and hydrofluoric acid treatment. Titanium samples in disk and cylinder forms were photofunctionalized by treatment with ultraviolet light for 15 min. The nanofeatured surface was converted from hydrophobic to superhydrophilic after photofunctionalization. The strength of osseointegration measured by a biomechanical push-in test in a rat model was stronger for photofunctionalized implants than for untreated implants by 2.2 and 2.3 times, respectively, at the early (week 2) and late (week 4) stages of healing, implying that photofunctionalization did not only accelerate but also increased the degree of osseointegration. Culture studies using bone marrow-derived osteoblasts showed that the attachment, spread, and functional phenotypes of osteogenic cells, such as alkaline phosphatase activity and mineralization, were remarkably increased on photofunctionalized titanium. In conclusion, photofunctionalization substantially increased biological and osseointegration capability of a nanofeatured titanium surface. In light with proven effectiveness on microfeatured surfaces in the literature, photofunctionalization may provide a novel and practical avenue to further improve osseointegration capability of implants in a wide range of surface morphology with micro-to-nano features.