DROSOPHILA PS1 INTEGRIN IS A LAMININ RECEPTOR AND DIFFERS IN LIGAND SPECIFICITY FROM PS2
DROSOPHILA PS1 INTEGRIN IS A LAMININ RECEPTOR AND DIFFERS IN LIGAND SPECIFICITY FROM PS2
复制标题
DOI：
10.1073/pnas.91.24.11447
复制
发表时间：
1994-11-22
影响因子：
11.1
通讯作者：
HYNES, RO
中科院分区：
文献类型：
--
作者：
GOTWALS, PJ;FESSLER, LI;HYNES, RO
我们在Schneider S2细胞表面表达了果蝇位置特异性整合素(PS)，并测试了其在各种基质分子上的黏附和铺展。我们报道了PS1整合素是一种层粘连蛋白受体，PS1和PS2整合素分别促进细胞在两种不同的果蝇细胞外基质分子LN和TIGGRIN上的扩散。这两种整合素不同的配体特异性，结合整合素及其配体在体内表达模式的数据，导致了果蝇蛹、翅和胚胎肌肉中整合素依赖的附着结构的模型。
We have expressed Drosophila position-specific (PS) integrins on the surfaces of Schneider S2 cells and tested for adhesion and spreading on various matrix molecules. We report that PS1 integrin is a laminin receptor and that PS1 and PS2 integrins promote cell spreading on two different Drosophila extracellular matrix molecules, laminin and tiggrin, respectively. The differing ligand specificities of these two integrins, combined with data on the in vivo expression patterns of the integrins and their ligands, lead to a model for the structure of integrin-dependent attachments in the pupal wing and embryonic muscles of Drosophila.