The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.
The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.
复制标题
脑单胺氧化酶：药物的选择性抑制及其对生物胺代谢的影响。
DOI：
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发表时间：
1974
影响因子：
3.5
通讯作者：
N. Neff
中科院分区：
文献类型：
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作者：
H. Y. Yang;N. Neff
在大鼠脑内发现了两种单胺氧化酶。这些酶被指定为A型和B型，被药物氯吉林（A型酶抑制剂）和丙炔苯丙胺（B型酶抑制剂）不同地抑制。这些药物，我们已经表明，这两种类型的酶是负责不同的胺在体内的代谢，并通过这些药物的管理，可以选择性地改变胺的代谢。例如，去甲肾上腺素和5-羟色胺是A型酶的首选底物，注射氯吉林可引起脑内这些胺的升高。β-苯乙胺是B型酶的首选底物，注射丙炔苯丙胺可减慢β-苯乙胺在脑内的代谢。与上述胺相反，多巴胺是两种酶的底物，注射任何一种药物都会导致多巴胺浓度升高。从我们的研究中，我们假设，它可能会改变选择性的代谢假定的递质胺在人的单胺氧化酶抑制剂药物，优先抑制一种特定类型的单胺氧化酶的管理。
Two types of monoamine oxidase were identified in vivo in rat brain. These enzymes, designated as type A and type B, were inhibited differentially by the drugs clorgyline (inhibitor of type A enzyme) and deprenyl (inhibitor of type B enzyme). With these drugs, we have shown that the two types of enzyme are responsible for the metabolism of different amines in vivo and that the metabolism of the amines can be altered selectively by administration of these drugs. For example, norepinephrine and serotonin were perferred substrates for type A enzyme and injection of clorgyline induced an elevation of these amines in brain. β-Phenylethylamine was a preferred substrate for type B enzyme and injection of deprenyl slowed the metabolism of β-phenylethylamine in brain. In contrast to the aforementioned amines, dopamine was a substrate for both enzymes and injection of either drug resulted in elevated dopamine concentrations. From our studies, we postulate that it may be possible to alter selectively the metabolism of the putative transmitter amines in man by administration of monoamine oxidase inhibitor drugs that preferentially inactivate a specific type of monoamine oxidase.