The role of platelet plasma growth factors in male pattern baldness surgery
The role of platelet plasma growth factors in male pattern baldness surgery
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DOI：
10.1097/01.prs.0000239560.29172.33
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发表时间：
2006-11-01
影响因子：
3.6
通讯作者：
Martins, Pedro
中科院分区：
文献类型：
--
作者：
Uebel, Carlos Oscar;da Silva, Jefferson Braga;Martins, Pedro
背景：毛囊单位通常用于脱发手术，并且它们已经成为男性和女性患者的全球程序。微型嫁接的产量在70%到85%之间。产量取决于以下因素，例如收获的供体区域的质量、单位的制备、在植入过程中的护理以及卵泡凋亡。为了提高头发密度和刺激毛囊单位的生长，使用血小板血浆生长因子从患者的自体plasma.Methods：作者建立了一个协议内的一组20例男性型秃发的实验研究。数据呈高斯分布;为了比较本临床试验中涉及的两种程序，使用配对t检验。结果：作者观察到实验区与对照区头皮相比，毛囊单位产量有显著差异（p < 0.001）。用血小板血浆生长因子治疗的区域显示出每平方厘米18.7个卵泡单位的产量，而对照区域每平方厘米16.4个卵泡单位，卵泡密度增加了15.1%。在使用实验方案的患者中，有些人只经历了3%，其他人经历了52%的增加density.Conclusions：这项研究提供了一个新的视角和贡献，脱发手术与毛囊单位megasessions，并证明了改进，可以引入到脱发手术诊所的发病率低，成本效益比。进一步的研究可能会提高该技术的效率，并允许数字程序更好地评估头发密度的增加。
Background: Follicular units are commonly used in baldness surgery, and they have become a global procedure for both male and female patients. The yield from micrografts varies between 70 and 85 percent. Yield is determined by factors such as quality of the harvested donor area, preparation of the units, care taken during the implantation procedure, and follicular apoptosis. To improve hair density and stimulate follicular unit growth, an experimental study was designed using platelet plasma growth factors obtained from the patient's autologous plasma.Methods: The author established a protocol within a group of 20 patients with male pattern baldness. The data showed a gaussian distribution; to compare the two procedures involved in this clinical trial, the paired t test was used.Results: The author observed a significant difference in the yield of follicular units when comparing the experimental with the control areas of the scalp (p < 0.001). The areas treated with platelet plasma growth factors demonstrated a yield of 18.7 follicular units per cm 2, whereas the control areas yielded 16.4 follicular units per cm(2), an increase in follicular density of 15.1 percent. Among patients who used the experimental protocol, some experienced only 3 percent and others experienced a 52 percent increase in density.Conclusions: This study provides a new perspective and contribution to baldness surgery with follicular unit megasessions, and demonstrates an improvement that can be introduced into baldness surgery clinics with less morbidity and a low cost-to-benefit ratio. Further studies may improve the efficiency of the technique and allow digital programs to better evaluate the increase in hair density.