Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
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DOI：
10.1152/japplphysiol.90880.2008
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发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Hargreaves, Mark
中科院分区：
文献类型：
--
作者：
Gibala, Martin J.;Mcgee, Sean L.;Hargreaves, Mark
Gibala MJ，McGee SL，Garnham AP，Howlett KF，Snow RJ，Hargreaves M.短暂的剧烈间歇运动激活AMPK和p38 MAPK信号并增加人骨骼肌中PGC-1 α的表达。J Appl Physiol 106：929-934，2009.首次发表于2008年12月26日; doi：10.1152/japplphysiol. 90880.2008.-从细胞信号传导的角度来看，短时间的高强度肌肉工作通常与阻力训练有关，并与刺激生长的途径有关。然而，短时间重复的短跑或高强度间歇运动会诱导类似于传统耐力训练的快速表型变化。我们测试了一个假设，即一个激烈的间歇性周期运动的急性会议将激活与人类骨骼肌线粒体生物合成的信号级联。从六名年轻男性身上获得了活检（股外侧肌），他们进行了四次30秒的“全力以赴”运动，中间休息4分钟（总功< 80 kJ）。AMP活化蛋白激酶（AMPK; α 1和α 2亚基）和p38丝裂原活化蛋白激酶（MAPK）的磷酸化水平高于对照组（P
Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1 alpha in human skeletal muscle. J Appl Physiol 106: 929-934, 2009. First published December 26, 2008; doi:10.1152/japplphysiol. 90880.2008.-From a cell signaling perspective, short-duration intense muscular work is typically associated with resistance training and linked to pathways that stimulate growth. However, brief repeated sessions of sprint or high-intensity interval exercise induce rapid phenotypic changes that resemble traditional endurance training. We tested the hypothesis that an acute session of intense intermittent cycle exercise would activate signaling cascades linked to mitochondrial biogenesis in human skeletal muscle. Biopsies (vastus lateralis) were obtained from six young men who performed four 30-s "all out" exercise bouts interspersed with 4 min of rest (< 80 kJ total work). Phosphorylation of AMP-activated protein kinase (AMPK; subunits alpha 1 and alpha 2) and the p38 mitogen-activated protein kinase (MAPK) was higher (P