Enhancement of NK Cell Cytotoxicity Induced by Long-Term Living in Negatively Charged-Particle Dominant Indoor Air-Conditions.
Enhancement of NK Cell Cytotoxicity Induced by Long-Term Living in Negatively Charged-Particle Dominant Indoor Air-Conditions.
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DOI：
10.1371/journal.pone.0132373
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Otsuki T
中科院分区：
文献类型：
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作者：
Nishimura Y;Takahashi K;Mase A;Kotani M;Ami K;Maeda M;Shirahama T;Lee S;Matsuzaki H;Kumagai-Takei N;Yoshitome K;Otsuki T
对促进健康的室内条件的调查显示，负电荷粒子主导的室内空气条件（NCPDIAC）诱导免疫刺激。在墙壁和天花板上涂上细炭粉，并利用室内空气中的强制负电荷颗粒（直径约为20纳米），通过在墙壁背面和地面之间施加电压（72 V）来建立负电荷空调。我们之前报道过，在这些条件下停留2.5小时后，这些条件诱导白细胞介素-2轻微而显着增加，在这些条件下停留两周后对人类受试者进行NK细胞毒性检查时，这些条件诱导白细胞介素-2轻微而显着增加。在目前的研究中，7名健康的志愿者在他们自己家里的起居室或卧室里安装了一个装置来产生NCPDIAC。每三个月，志愿者们打开或关闭NCPDIAC设备。共进行了16次ON试验和13次OFF试验，并对其生物学效应进行了分析。NK活性在ON试验期间升高，在OFF试验期间降低，但未发现其他不良反应。此外，在ON试验期间，表皮生长因子（EGF）略有增加。此外，比较ON和OFF试验的细胞因子状态显示，在NCPIADC下ON试验时，基本免疫状态略有刺激。我们的总体研究结果表明，NCPDIAC装置引起NK活性的激活并刺激免疫状态，特别是仅对NK活性，因此可以在家中或办公楼中设置。
Investigation of house conditions that promote health revealed that negatively charged-particle dominant indoor air-conditions (NCPDIAC) induced immune stimulation. Negatively charged air-conditions were established using a fine charcoal powder on walls and ceilings and utilizing forced negatively charged particles (approximate diameter: 20 nm) dominant in indoor air-conditions created by applying an electric voltage (72 V) between the backside of the walls and the ground. We reported previously that these conditions induced a slight and significant increase of interleukin-2 during a 2.5-h stay and an increase of NK cell cytotoxicity when examining human subjects after a two-week night stay under these conditions. In the present study, seven healthy volunteers had a device installed to create NCPDIAC in the living or sleeping rooms of their own homes. Every three months the volunteers then turned the NCPDIAC device on or off. A total of 16 ON and 13 OFF trials were conducted and their biological effects were analyzed. NK activity increased during ON trials and decreased during OFF trials, although no other adverse effects were found. In addition, there were slight increases of epidermal growth factor (EGF) during ON trials. Furthermore, a comparison of the cytokine status between ON and OFF trials showed that basic immune status was stimulated slightly during ON trials under NCPIADC. Our overall findings indicate that the NCPDIAC device caused activation of NK activity and stimulated immune status, particularly only on NK activity, and therefore could be set in the home or office buildings.