Cellular immune responses in neonates.
Cellular immune responses in neonates.
复制标题
DOI：
10.3109/08830180009088504
复制
发表时间：
2000-01-01
影响因子：
5
通讯作者：
Sarzotti, M
中科院分区：
文献类型：
--
作者：
Fadel, S;Sarzotti, M
淋巴细胞和抗原提呈细胞的数量减少被描述为导致新生儿抗原性耐受或低反应性的一些主要因素。然而，通过改变免疫参数，如抗原剂量和抗原提呈细胞频率，我们和其他人已经表明，新生儿可以选择发展与成人相同的各种免疫反应。本文综述了新生儿和小鼠细胞免疫发展的几个方面，特别是T细胞介导的反应的发展，从个体发育到效应功能。
Reduced numbers of lymphocytes and antigen presenting cells have been described as some of the main factors responsible for antigenic tolerance or low responsiveness in neonates. However, by changing the parameters of immunization, such as dose of antigen and frequency of antigen presenting cells we and others have shown that neonates have the option of developing the same variety of immune responses seen in adults. Several aspects of the development of cellular immunity in human and murine neonates are reviewed in this article, with a special focus on the development of T cell mediated responses, from ontogeny to effector function.