Biodistribution and biocompatibility of glycyrrhetinic acid and galactose-modified chitosan nanoparticles as a novel targeting vehicle for hepatocellular carcinoma
Biodistribution and biocompatibility of glycyrrhetinic acid and galactose-modified chitosan nanoparticles as a novel targeting vehicle for hepatocellular carcinoma
复制标题
甘草次酸和半乳糖修饰的壳聚糖纳米颗粒作为肝细胞癌新型靶向载体的生物分布和生物相容性
DOI：
10.2217/nnm-2018-0455
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发表时间：
2020-01-01
期刊：
影响因子：
5.5
通讯作者：
Zheng, Qi Chang
中科院分区：
文献类型：
--
作者：
Li, Min;Wang, Yan;Zheng, Qi Chang
目的：设计了大黄酸和半乳糖双配体修饰的壳聚糖纳米粒，以进一步提高其对肝癌的靶向性。材料和方法：采用离子凝胶法制备了大黄酸和半乳糖双配体修饰的壳聚糖纳米粒，并对其性质进行了表征。此外，该靶向载体的生物分布和生物相容性分别在体外和体内进行了研究。结果如下：靶向载体在体外特异性内化到肝癌细胞中，并在体内高效地积聚到肿瘤组织中。此外，溶剂不诱导炎症反应，不影响形态学和器官功能。结论：双配体修饰的壳聚糖纳米粒在肝癌组织中的靶向积聚和良好的生物相容性突出了将抗癌药物递送到肝癌细胞中的潜力。
Aim: The dual-ligand glycyrrhetinic acid and galactose-modified chitosan nanoparticles were designed to further improve the targeting capability to hepatocellular carcinoma (HCC). Materials & methods: The dual-ligand glycyrrhetinic acid and galactose-modified chitosan nanoparticles were fabricated by using ionic gelation method and their characteristics have been measured. Furthermore, the biodistribution and biocompatibility of this targeting vehicle were investigated in vitro and in vivo, respectively. Results: The targeting vehicle was specifically internalized into hepatoma cells in vitro and accumulated into tumor tissue in vivo with high efficacy. Moreover, the vehicle did not induce inflammation reaction and affect morphologies and organ functions. Conclusion: The targeting accumulation in HCC tissue and great biocompatibility of the dual-ligand modified chitosan nanoparticles highlight the potential of delivering anticancer agents into HCC cells.