Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder
Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder
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DOI：
10.1007/s11682-016-9611-9
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Nakagawa, Akiko
中科院分区：
文献类型：
--
作者：
Hirose, Motohisa;Hirano, Yoshiyuki;Nakagawa, Akiko
强迫症（OCD）是一种以症状维度为特征的临床异质性疾病。尽管大量的神经影像学研究已经证明强迫症患者存在大脑异常，但其结果仍存在争议。强迫症的临床异质性可能是其中一个原因。据推测，大脑的某些区域导致了各自的强迫症维度。在这项研究中，我们使用基于体素的形态测量法研究强迫症症状维度与大脑形态之间的关系，以发现在强迫症症状各自维度上显示改变的特定区域。采用强迫量表（OCI-R）对33例强迫症患者进行症状维度的严重程度评估。随着大量的MRI研究指出自闭症谱系障碍（ASD）患者的大脑异常，之前的一项研究报道了自闭症谱系障碍特征与强迫症患者左背外侧前额叶皮层和杏仁核区域灰质体积呈正相关。我们研究了全脑水平的灰质和白质体积与每个症状维度评分之间的相关性，并将所有剩余维度评分、年龄、性别和ASD特征作为混杂协变量。结果表明，洗涤症状维度得分与右丘脑灰质体积呈显著负相关，囤积症状维度得分与左脑角回白质体积呈显著负相关。虽然我们的结果是初步的，但我们的发现表明，强迫症患者的症状维度与大脑灰质和白质中的特定区域有关。
Obsessive-compulsive disorder (OCD) is known as a clinically heterogeneous disorder characterized by symptom dimensions. Although substantial numbers of neuroimaging studies have demonstrated the presence of brain abnormalities in OCD, their results are controversial. The clinical heterogeneity of OCD could be one of the reasons for this. It has been hypothesized that certain brain regions contributed to the respective obsessive-compulsive dimensions. In this study, we investigated the relationship between symptom dimensions of OCD and brain morphology using voxel-based morphometry to discover the specific regions showing alterations in the respective dimensions of obsessive-compulsive symptoms. The severities of symptom dimensions in thirty-three patients with OCD were assessed using Obsessive-Compulsive Inventory-Revised (OCI-R). Along with numerous MRI studies pointing out brain abnormalities in autistic spectrum disorder (ASD) patients, a previous study reported a positive correlation between ASD traits and regional gray matter volume in the left dorsolateral prefrontal cortex and amygdala in OCD patients. We investigated the correlation between gray and white matter volumes at the whole brain level and each symptom dimension score, treating all remaining dimension scores, age, gender, and ASD traits as confounding covariates. Our results revealed a significant negative correlation between washing symptom dimension score and gray matter volume in the right thalamus and a significant negative correlation between hoarding symptom dimension score and white matter volume in the left angular gyrus. Although our result was preliminary, our findings indicated that there were specific brain regions in gray and white matter that contributed to symptom dimensions in OCD patients.