OLIGODEOXYNUCLEOTIDE ANALOGS WITH 5'-LINKED ANTHRAQUINONE
OLIGODEOXYNUCLEOTIDE ANALOGS WITH 5'-LINKED ANTHRAQUINONE
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DOI：
10.1016/0014-5793(89)80626-x
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发表时间：
1989-06-05
期刊：
影响因子：
3.5
通讯作者：
COHEN, JS
中科院分区：
文献类型：
--
作者：
MORI, K;SUBASINGHE, C;COHEN, JS
我们在此报告了新型 5' 连接寡脱氧核苷酸的合成，包括正常的磷酸二酯和硫代磷酸酯类似物，其中 5' 末端的共价连接基团是蒽醌。这些化合物代表了一类新的反义化合物，其中寡脱氧核苷酸的碱基序列用于将核酸酶抗性反应性药物样分子递送至细胞靶核酸（mRNA或DNA）。
We report here the synthesis of novel 5′‐linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′‐terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease‐resistant reactive drug‐like molecule to a cellular target nucleic acid (mRNA or DNA).