Nosocomial outbreak of Burkholderia pickettii infection due to a manufactured intravenous product used in three hospitals.
Nosocomial outbreak of Burkholderia pickettii infection due to a manufactured intravenous product used in three hospitals.
复制标题
由于三家医院使用制造的静脉注射产品，爆发了皮氏伯克霍尔德氏菌感染的院内疫情。
DOI：
10.1093/clinids/22.6.1092
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
J. Fereres
中科院分区：
文献类型：
--
作者：
C. Fernández;I. Wilhelmi;E. Andradas;C. Gaspar;J. Gómez;J. Romero;J. Mariano;O. Corral;M. Rubio;J. Elviro;J. Fereres
1993年6月至11月，马德里的三家大城市医院报告了46例由伯克霍尔德氏菌引起的医院感染。对暴发进行了病例对照研究，以确定其原因。74%的患者为男性；患者平均年龄+/-SD为54+/-20岁。65%的患者出现一些胃肠道疾病，80%的患者有外周导管；98%的患者接受静脉输液治疗，96%的患者接受雷尼替丁静脉治疗。根据描述性研究的结果和对皮克氏杆菌流行病学特征的了解，提出了一个暂定的因果假设：静脉注射雷尼替丁是暴发的来源。作为一项控制措施，建议停止使用这种药物治疗。根据Logistic回归分析结果和药瓶中的微生物分离结果，我们得出结论，静脉注射雷尼替丁是此次暴发的原因。
Forty-six cases of nosocomial infection caused by Burkholderia pickettii were reported between June and November 1993 in three metropolitan hospitals in Madrid. A case-control study of the outbreak was conducted to identify its cause. Seventy-four percent of the patients were males; the mean age +/- SD of the patients was 54 +/- 20 years. Sixty-five percent of the patients presented with some gastrointestinal disorder, and 80% had a peripheral catheter; 98% were treated with intravenous fluids, and 96% were treated with intravenous ranitidine. On the basis of results of a descriptive study and knowledge of the epidemiologic features of B. pickettii, a provisional causal hypothesis was formulated: intravenous ranitidine was the source of the outbreak. As a control measure, it was advised to stop treatment with this drug. On the basis of results of logistic regression and the microbiological isolation of B. pickettii in an ampule of the drug, we concluded that intravenous ranitidine was the cause of the outbreak.