Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study
Limitations of current definitions of miscarriage using mean gestational sac diameter and crown-rump length measurements: a multicenter observational study
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DOI：
10.1002/uog.10109
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发表时间：
2011-11-01
影响因子：
7.1
通讯作者：
Bourne, T.
中科院分区：
文献类型：
--
作者：
Abdallah, Y.;Daemen, A.;Bourne, T.
目的 用于定义流产的平均孕囊直径 (MSD) 和胚胎冠臀长度 (CRL) 的截止值存在显着差异，文献中建议的 MSD 值范围为 13 至 25 毫米，CRL 值范围为 3 至 8 毫米。我们的目的是在大量早孕诊所就诊的患者群体中，确定与不同 CRL 和 MSD 测量（有或没有卵黄囊）相关的流产诊断假阳性率 (FPR)。我们还旨在定义 CRL 和 MSD 的临界值，在单次测量的基础上，可以明确诊断流产，从而排除可能的意外终止妊娠。方法这是一项观察性横断面研究。根据预定义的协议前瞻性地收集数据。生存能力不确定的宫内妊娠 (IPUV) 被定义为空孕囊或带有卵黄囊但没有看到 MSD 25 mm 且 CRL 截止值 > 7 mm 的胚胎，以最大程度地降低流产假阳性诊断的风险。版权。 (C) 2011 ISUOG。由约翰·威利父子有限公司出版
Objectives There is significant variation in cut-off values for mean gestational sac diameter (MSD) and embryo crown-rump length (CRL) used to define miscarriage, values suggested in the literature ranging from 13 to 25 mm for MSD and from 3 to 8 mm for CRL. We aimed to define the false-positive rate (FPR) for the diagnosis of miscarriage associated with different CRL and MSD measurements with or without a yolk sac in a large study population of patients attending early pregnancy clinics. We also aimed to define cut-off values for CRL and MSD that, on the basis of a single measurement, can definitively diagnose a miscarriage and so exclude possible inadvertent termination of pregnancy.Methods This was an observational cross-sectional study. Data were collected prospectively according to a predefined protocol. Intrauterine pregnancy of uncertain viability (IPUV) was defined as an empty gestational sac or sac with a yolk sac but no embryo seen with MSD 25 mm and a CRL cut-off of >7 mm could be introduced to minimize the risk of a false-positive diagnosis of miscarriage. Copyright. (C) 2011 ISUOG. Published by John Wiley & Sons, Ltd.