Severe Asthma Lessons Learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program
Severe Asthma Lessons Learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program
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DOI：
10.1164/rccm.201107-1317pp
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发表时间：
2012-02-15
影响因子：
24.7
通讯作者：
Busse, William W.
中科院分区：
文献类型：
--
作者：
Jarjour, Nizar N.;Erzurum, Serpil C.;Busse, William W.
美国国家心脏、肺和血液研究所严重哮喘研究项目（SARP）在过去10年中对1,644名哮喘患者进行了研究，其中包括583名严重哮喘患者。SARP的合作导致了受试者的快速招募和参与研究中心之间有效的样本共享，以进行严重哮喘的独立机制研究。入组的SARP受试者接受了详细的临床、生理、基因组和放射学评价。此外，SARP研究人员开发了安全的支气管镜检查程序，用于哮喘参与者，包括那些患有严重疾病的人。SARP研究表明，严重哮喘是一种异质性疾病，具有不同的分子，生化和细胞炎症特征和独特的结构-功能异常。未来研究的优先事项包括招募大量重度哮喘受试者（包括儿童），以便在纵向评估中进一步表征与重度疾病相关的解剖、生理、生化和遗传因素，以确定调节重度哮喘自然史的因素，并为管理策略提供机制依据。
The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals with severe asthma. SARP collaboration has led to a rapid recruitment of subjects and efficient sharing of samples among participating sites to conduct independent mechanistic investigations of severe asthma. Enrolled SARP subjects underwent detailed clinical, physiologic, genomic, and radiological evaluations. In addition, SARP investigators developed safe procedures for bronchoscopy in participants with asthma, including those with severe disease. SARP studies revealed that severe asthma is a heterogeneous disease with varying molecular, biochemical, and cellular inflammatory features and unique structure-function abnormalities. Priorities for future studies include recruitment of a larger number of subjects with severe asthma, including children, to allow further characterization of anatomic, physiologic, biochemical, and genetic factors related to severe disease in a longitudinal assessment to identify factors that modulate the natural history of severe asthma and provide mechanistic rationale for management strategies.