Immune function in aged women is improved by ingestion of vitamins C and E
Immune function in aged women is improved by ingestion of vitamins C and E
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DOI：
10.1139/cjpp-76-4-373
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发表时间：
1998-04-01
影响因子：
2.1
通讯作者：
Miquel, J
中科院分区：
文献类型：
--
作者：
De la Fuente, M;Ferrández, MD;Miquel, J
我们研究了在饮食中补充抗氧化剂维生素C和E对老年妇女免疫反应的几种功能的影响。10名健康女性和20名患有两种通常与年龄相关的疾病（10名患有重度抑郁症，MDD，10名患有冠心病，CHD）的女性（72 +/- 6岁）每天服用1 g维生素C和200 mg维生素E，持续16周。在治疗前后收集血液样品用于测量几种免疫功能，即淋巴细胞对促分裂原植物血凝素（20 mg/L）的增殖反应和多形核白细胞（PMN）嗜中性粒细胞的吞噬功能，即，粘附于血管内皮、趋化性、乳胶珠的吞噬作用和超氧阴离子的产生。此外，我们还测定了血清皮质醇和脂质过氧化物的水平。摄入维生素导致淋巴细胞增殖能力和中性粒细胞的吞噬功能显着增加，以及在血清过氧化脂质和皮质醇水平显着降低，无论是在健康的老年妇女和老年妇女与MDD或CHD。这些研究结果表明，抗氧化剂补充剂在改善老年女性的免疫功能以及预防和治疗发达国家相当普遍的与年龄相关的特定疾病方面具有重要作用。
We have investigated the effects of supplementation of the diet with the antioxidant vitamins C and E on several functions of the immune response of aged women. Ten healthy women and 20 women (72 +/- 6 years old) suffering two diseases often associated with age (10 with major depression disorders, MDD, and 10 with coronary heart disease, CHD) were administered 1 g of vitamin C and 200 mg of vitamin E daily for 16 weeks. Blood samples were collected before and after treatment for measurement of several immunological functions, namely proliferative response of lymphocytes to the mitogen phytohemagglutinin (20 mg/L) and phagocytic functions of polymorphonuclear (PMN) neutrophils, i.e., adherence to vascular endothelium, chemotaxis, phagocytosis of latex beads, and superoxide anion production. In addition, we also determined the levels of serum cortisol and lipid peroxides. Intake of vitamins resulted in a significant increase in the lymphoproliferative capacity and in the phagocytic functions of PMN neutrophils as well as in a significant decrease of serum levels of lipid peroxides and cortisol, both in the healthy aged women and in the aged women with MDD or CHD. These findings suggest an important role of antioxidant supplementation in the improvement of immune function in aged females as well as in the prevention and treatment of specific diseases associated with age that are quite prevalent in the developed countries.