Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces
Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces
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DOI：
10.12938/bmfh.2019-045
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发表时间：
2020-01-01
影响因子：
3.1
通讯作者：
Murayama, Norihito
中科院分区：
文献类型：
--
作者：
Fukizawa, Shinya;Yamashita, Mai;Murayama, Norihito
本研究的目的是验证异黄腐酚（IX）处理对小鼠粪便代谢组学谱的影响，以在分子水平上探索宿主-肠道细菌相互作用。高脂饲料（HFD）+0.1%IX组（IX混合饲料处理12周）的粪便中几种氨基酸含量显著低于HFD组。HFD + 180 mg/kg IX组（经口给予IX 8周）粪便中次级胆汁酸脱氧胆酸（DCA）含量显著低于HFD组; HFD组的值高于正常饮食（ND）组。给予IX改变了粪便代谢组学特征。对于某些代谢物，IX使HFD诱导的波动标准化。
The aim of this study was to verify the effect of treatment with isoxanthohumol (IX) on the metabolomics profile of mouse feces to explore the host-intestinal bacterial interactions at the molecular level. The fecal contents of several amino acids in the high-fat diet (HFD) + 0.1% IX group (treated with IX mixed in diets for 12 weeks) were significantly lower than in the HFD group. The fecal contents of the secondary bile acid deoxycholic acid (DCA) in the HFD + 180 mg/kg IX group (orally treated with IX for 8 weeks) were significantly lower than in the HFD group; the values in the HFD group were higher than those in the normal diet (ND) group. Administration of IX changed the fecal metabolomics profile. For some metabolites, IX normalized HFD-induced fluctuations.