Selected players in the inflammation cascade and drugs that target these inflammation genes against metastasis
Selected players in the inflammation cascade and drugs that target these inflammation genes against metastasis
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DOI：
10.2174/187152006778226477
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Pillarisetti, Sivaram
中科院分区：
文献类型：
--
作者：
Alikunju, Shanavas;Pillarisetti, Sivaram
尽管最近取得了许多进展，但具有转移的癌症患者的预后仍然很差。在转移侵袭中，肿瘤细胞通过几种不同的粘附分子与内皮细胞相互作用。粘附的肿瘤细胞通过用基质降解酶如乙酰肝素酶和基质金属蛋白酶降解基底膜而外渗到组织中。基质降解酶和粘附分子的内皮表达受炎性细胞因子的控制。这些炎症蛋白和参与这些基因表达的信号通路作为预防肿瘤生长和转移的治疗靶点正在进行深入研究。目前的审查集中在炎症级联反应的选定球员和药物，针对这些炎症基因。
Despite many recent advances the prognosis of cancer patients with metastasis still remains poor. In metastatic invasion, tumor cells interact with endothelial cells through several distinct adhesion molecules. Adherent tumor cells extravasate into tissues by degrading basement membranes with matrix degrading enzymes such as heparanases and matrix metalloproteinases. Endothelial expression of matrix degrading enzymes and adhesion molecules are under the control of inflammatory cytokines. These inflammatory proteins and the signaling pathways involved in the expression of these genes are under intense investigation as therapeutic targets to prevent tumor growth and metastasis. The current review focuses on selected players of the inflammation cascade and drugs that target these inflammatory genes.