PUBERTAL DEVELOPMENT AND TESTICULAR FUNCTION IN THE MALE GROWTH HORMONE-DEFICIENT RAT
PUBERTAL DEVELOPMENT AND TESTICULAR FUNCTION IN THE MALE GROWTH HORMONE-DEFICIENT RAT
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DOI：
10.1677/joe.0.1260193
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发表时间：
1990-08-01
影响因子：
4
通讯作者：
NIESCHLAG, E
中科院分区：
文献类型：
--
作者：
BARTLETT, JMS;CHARLTON, HM;NIESCHLAG, E
对一种新的生长激素缺乏突变体--矮小鼠的青春期发育进行了评估。小睾丸内正常生精功能的建立表明，GH在青春期和成年期的生精功能中没有作用。然而，睾丸大小的减少可能反映了支持细胞数量的减少，这表明GH在青春期前睾丸的发育中可能是重要的。此外，纯合子矮小鼠和纯合子生长激素缺乏突变体(如嗅觉、Ames、侏儒和小突变体)之间的显著差异已被证明。看来，大鼠突变体中的生长激素缺乏症比迄今为止在小鼠中描述的生长激素缺陷更具特异性。与Snell矮小突变体相比，矮小大鼠在整个青春期发育过程中，脑垂体和血清中FSH和LH的浓度是正常的。生精功能和精囊功能均发育正常，而斯奈尔矮小鼠生精功能发育较晚，精囊仍处于婴儿期。侏儒大鼠的血清和睾丸雄激素浓度也是正常的。在以前的研究中，纯合子侏儒大鼠被证明具有生育能力；然而，我们的观察表明，尽管在组织学评估时，精子发生在质量和数量上都是正常的，但矮小大鼠的睾丸大小会导致这些动物的每日精子产量减少。矮小大鼠代表了一种突变体，在这种突变体中，生长激素选择性耗竭的后果可能会对各种内分泌系统进行研究。在幼年时期，生殖轴似乎只受到生长激素缺乏的部分影响。
The pubertal development of a novel GH-deficient mutant, the dwarf rat, has been evaluated. The establishment of normal spermatogenic function within small testes suggests that GH plays no role in spermatogenic function during puberty and adult life. However, a reduction in testicular size may reflect a reduced Sertoli cell population suggesting that GH may be of importance in prepubertal testicular development. Furthermore marked differences between the homozygous dwarf rat and homozygous GH-deficient mouse mutants (e.g. Smell, Ames, pygmy and little mutants) have been demonstrated. It would appear that the GH deficiency in the rat mutant is far more specific for GH than those hitherto described in the mouse. In contrast to Snell dwarf mutants, pituitary and serum concentrations of FSH and LH are normal throughout pubertal development in the dwarf rat. Both spermatogenic function and seminal vesicle function develop normally, whilst in Snell dwarf mice spermatogenic function develops late in life and seminal vesicles remain infantile. Serum and testicular concentrations of androgen are also normal in dwarf rats. Homozygous dwarf rats have been shown to ge fertile in previous studies; however our observations suggest that despite spermatogenesis being qualitatively and quantitatively normal when assessed histologically, reduced testicular size seen in dwarf rats would lead to a reduced daily sperm output in these animals. The dwarf rat represents a mutant in which the consequences of the selective depletion of GH may be studied on various endocrine systems. The reproductive axis appears to be only partially affected at an early age, by GH deficiency.